Article Text

Download PDFPDF

Letter
Posterior reversible encephalopathy syndrome associated with SARS-CoV-2 infection
  1. Abdenour Djellaoui,
  2. Lilia Seddik,
  3. Laurent Cleret De Langavant,
  4. Samuel Cattan,
  5. Anne Catherine Bachoud-Lévi,
  6. Hassan Hosseini
  1. Neurology, Henri Mondor University Hospitals, APHP, Créteil, France
  1. Correspondence to Dr Abdenour Djellaoui, Neurology, Hospital Group Henri Mondor, 94010 Créteil, France; abdenour.djellaoui{at}aphp.fr

Statistics from Altmetric.com

Introduction

The symptoms of COVID-19 include fever, fatigue and respiratory illness ranging from cough to acute respiratory distress syndrome (ARDS).1 Neurological complications, such encephalopathy, are more and more reported. They can result from direct viral invasion, hypoxic, toxic or immune-mediated injury. In this report, we describe a patient with posterior reversible encephalopathy syndrome (PRES) associated with SARS-CoV-2 infection.

Case description

The patient is a 69-year-old woman, with history of coronary artery disease, an endometrial cancer, in remission since 2006 and a right breast cancer without anticancer treatment and in remission since 2018, and no history of hypertension. She presented to the stroke unit, in the end of March 2020, few days before the epidemic peak in France, for three generalised seizures, mutism and delirium, and 7 days’ history of unusual asthenia. Temperature was 37°C, blood pressure at 200/116 mm Hg and oxygen saturation was 95% while she was breathing ambient air. The pulmonary examination was normal. Neurological examination found no focal motor or sensor deficit. Brain MRI, performed 5 hours after the onset of seizures, showed bilateral and symmetric T2 and fluid-attenuated inversion recovery imaging hyperintensities located mainly in the temporal and occipital lobes with increased apparent diffusion coefficient values and leptomeningeal enhancement in the same areas in 3D T1 gadolinium sequence (figure 1). There were no signs of intracranial haemorrhage in susceptibility weighted imaging (images not shown). The vessel’s imaging was normal. The electroencephalogram showed intermittent focal slow delta waves in posterior …

View Full Text

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.