Article Text

Download PDFPDF
Letter
Utilisation of retinal vein photoplethysmography to measure intracranial pressure
  1. William H Morgan1,
  2. Ying Jo Khoo1,
  3. Allan G Kermode2,3,
  4. Christopher R Lind4,5,
  5. Martin L Hazelton6,
  6. Kirsty E Parsons6,
  7. Dao Yi Yu1
  1. 1Lions Eye Institute, Centre for Ophthalmology and Visual Science, University of Western Australia, Crawley, Western Australia, Australia
  2. 2Centre for Neuromuscular and Neurological Disorders, Perron Institute for Neurological and Translational Science, Sir Charles Gairdner Hospital Department of Neurology and Clinical Neurophysiology, Nedlands, Western Australia, Australia
  3. 3Institute for Immunology and Infectious Disease, Murdoch University Faculty of Health Sciences, Murdoch, Western Australia, Australia
  4. 4Neurosurgical Service of Western Australia, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
  5. 5Department of Surgery, University of Western Australia, Crawley, Western Australia, Australia
  6. 6School of Fundamental Sciences, Massey University, Palmerston North, Manawatu-Wanganui, New Zealand
  1. Correspondence to Professor William H Morgan, Lions Eye Institute, Centre for Ophthalmology and Visual Science, University of Western Australia, Crawley, WA 6009, Australia; billmorgan{at}lei.org.au

Statistics from Altmetric.com

We would like to present our assessment and describe the accuracy of a retinal vein pulse amplitude photoplethysmographic (PPG) technique for non-invasively estimating intracranial pressure (ICP), which is a fundamental physiological parameter in neurological disease. Current ICP measurement techniques use external ventricular drain (EVD), pressure transducer implantation or cannulation of the lumbar cerebrospinal fluid space via lumbar puncture (LP) with risks of infection, haemorrhage and headache. Comparing LP to EVD pressure measures shows high concordance with SD of measured differences being just 2.1 mm Hg and 95% of differences falling between −5.1 to +2.6 mm Hg.1 We take PPG measures of venous pulse amplitude at varying intraocular pressure (IOP) to estimate the ICP/IOP balance point and hence the ICP. We present data from a cohort of neurological and neurosurgical patients comparing our estimates to invasive ICP estimates.

With institutional ethics approval, suitable neurosurgical patients with EVD and neurology patients within 2 days prior to undergoing LP were recruited. Suitability included being able to sit at a slit lamp for 10 min and being deemed fit for such examination by their clinical team. The PPG measurements were performed through an ophthalmodynamometry lens (Meditron, Volklingen, Germany) at a video slit lamp camera recording at 25 fps (Canon 5D mark III, Japan). A pulse oximeter was used to time the video-recordings in terms …

View Full Text

Footnotes

  • Contributors WHM: design and conceptualised study, examined patients. YJK: Examined patients, performed photoplethysmography analysis. AGK: performed lumbar puncture, design of study. CRL: performed EVD, study design and conceptualisation. MLH: study design, conceptualisation, designed harmonic analysis for study. KEP: designed and implemented modified broken stick data analysis. DYY: design and conceptualised study, manuscript preparation.

  • Funding National Health and Medical Research Council (NHMRC) of Australia grant APP107310

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.