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Neurite orientation dispersion and density imaging discloses early changes in the normal-appearing white matter in paediatric multiple sclerosis

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Footnotes

  • Contributors MM: drafting/revising the manuscript, study concept, and acquisition, analysis and interpretation of the data. UV and LF: drafting/revising the manuscript, analysis and interpretation of the data. SF, MR, MN, SS, MAG, FC, PP and FR: drafting/revising the manuscript and acquisition of the data. AB: drafting/revising the manuscript, acquisition and interpretation of the data and study supervisor. PG: drafting/revising the manuscript, study concept, acquisition and interpretation of the data and study supervisor.

  • Funding We thank Biogen for their financial support (no award/grant number).

  • Competing interests Monica Margoni reports grants and personal fees from Sanofi Genzyme, Merck Serono, Novartis and Almirall. She was awarded a MAGNIMS-ECTRIMS fellowship in 2020. Umberto Villani, Livio Finos, Silvia Franciotta, Martina Rubin, Margherita Nosadini, Stefano Sartori, Maria Giulia Anglani, Francesco Causin, Alessandra Bertoldo have nothing to disclose. Francesca Rinaldi reports grants and personal fees from Sanofi Genzyme, Merck Serono, Biogen and Novartis. Paola Perini reports grants and personal fees from Merck Serono, Biogen, Sanofi Genzyme, Roche, Bayer Schering Pharma and Novartis. Paolo Gallo reports grants and personal fees from Merck Serono, Biogen, Sanofi Genzyme, Roche, Bayer Schering Pharma, Novartis, University of Padua, Department of Neurosciences DNS, Veneto Region of Italy, Italian Association for Multiple Sclerosis (AISM) and Italian Ministry of Public Health.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise.

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