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The cerebellum in ALS: friend or foe?
  1. Pierre-Francois Pradat1,2
  1. 1APHP, Department of Neurology, Pitie-Salpetriere University Hospital, Paris, France
  2. 2Sorbonne University, CNRS, INSERM, Laboratory of Biomedical Imaging, Paris, France
  1. Correspondence to Dr Pierre-Francois Pradat, Département de Neurologie, Hopital Universitaire Pitie Salpetriere, Paris, Île-de-France, France; pierre-francois.pradat{at}psl.aphp.fr

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A new MRI study suggests that cerebellar degeneration may contribute to motor and non-motor symptoms in amyotrophic lateral sclerosis

Bede et al present an intriguing study of cerebellar degeneration in amyotrophic lateral sclerosis (ALS).1 The authors revisit a contentious facet of ALS to present novel insights into cerebellar pathology. ALS is primarily associated with motor cortex and pyramidal tract degeneration, but accompanying frontotemporal involvement is also commonly observed. Extrapyramidal and cerebellar involvement is less well characterised, despite compelling radiological and postmortem evidence.2 3 Positron emission tomography studies often detect hypermetabolic changes in the cerebellum, but the molecular underpinnings of these changes are not entirely clear and a variety of conflicting explanations have been offered. It has been repeatedly suggested …

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  • Contributors I am the sole author of this editorial.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.

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