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  • Plasma NfL levels and longitudinal change rates in C9orf72 and GRN-associated diseases: from tailored references to clinical applications

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Neurogenetics
Original research
Plasma NfL levels and longitudinal change rates in C9orf72 and GRN-associated diseases: from tailored references to clinical applications

Authors

  • Dario Saracino Sorbonne Université, Paris Brain Institute - Institut du Cerveau - ICM, Inserm U1127, CNRS UMR 7225, AP-HP - Hôpital Pitié-Salpêtrière, Paris, France Reference Centre for Rare or Early Dementias, IM2A, Départment de Neurologie, AP-HP - Hôpital Pitié-Salpêtrière, Paris, France Aramis Project Team, Inria Paris Research Centre, Paris, France PubMed articlesGoogle scholar articles
  • Karim Dorgham Sorbonne Université, INSERM, Centre d’Immunologie et des Maladies Infectieuses-Paris (CIMI-Paris), Paris, France PubMed articlesGoogle scholar articles
  • Agnès Camuzat Sorbonne Université, Paris Brain Institute - Institut du Cerveau - ICM, Inserm U1127, CNRS UMR 7225, AP-HP - Hôpital Pitié-Salpêtrière, Paris, France EPHE, PSL Research University, Paris, France PubMed articlesGoogle scholar articles
  • Daisy Rinaldi Sorbonne Université, Paris Brain Institute - Institut du Cerveau - ICM, Inserm U1127, CNRS UMR 7225, AP-HP - Hôpital Pitié-Salpêtrière, Paris, France Reference Centre for Rare or Early Dementias, IM2A, Départment de Neurologie, AP-HP - Hôpital Pitié-Salpêtrière, Paris, France PubMed articlesGoogle scholar articles
  • Armelle Rametti-Lacroux Inserm U 1127, CNRS UMR 7225, Sorbonne Université, Paris Brain Institute–Institut du Cerveau (ICM), FRONTlab, Paris, France PubMed articlesGoogle scholar articles
  • Marion Houot Sorbonne Université, Paris Brain Institute - Institut du Cerveau - ICM, Inserm U1127, CNRS UMR 7225, AP-HP - Hôpital Pitié-Salpêtrière, Paris, France Reference Centre for Rare or Early Dementias, IM2A, Départment de Neurologie, AP-HP - Hôpital Pitié-Salpêtrière, Paris, France Centre of Excellence of Neurodegenerative Disease (CoEN), ICM, CIC Neurosciences, Département de Neurologie, AP-HP, Hôpital Pitié-Salpêtrière, Sorbonne Université, Paris, France PubMed articlesGoogle scholar articles
  • Fabienne Clot UF de Neurogénétique Moléculaire et Cellulaire, Département de Génétique, AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière-Charles Foix, Paris, France PubMed articlesGoogle scholar articles
  • Philippe Martin-Hardy Sorbonne Université, Paris Brain Institute - Institut du Cerveau - ICM, Inserm U1127, CNRS UMR 7225, AP-HP - Hôpital Pitié-Salpêtrière, Paris, France PubMed articlesGoogle scholar articles
  • Ludmila Jornea Sorbonne Université, Paris Brain Institute - Institut du Cerveau - ICM, Inserm U1127, CNRS UMR 7225, AP-HP - Hôpital Pitié-Salpêtrière, Paris, France PubMed articlesGoogle scholar articles
  • Carole Azuar Sorbonne Université, Paris Brain Institute - Institut du Cerveau - ICM, Inserm U1127, CNRS UMR 7225, AP-HP - Hôpital Pitié-Salpêtrière, Paris, France Reference Centre for Rare or Early Dementias, IM2A, Départment de Neurologie, AP-HP - Hôpital Pitié-Salpêtrière, Paris, France Inserm U 1127, CNRS UMR 7225, Sorbonne Université, Paris Brain Institute–Institut du Cerveau (ICM), FRONTlab, Paris, France PubMed articlesGoogle scholar articles
  • Raffaella Migliaccio Sorbonne Université, Paris Brain Institute - Institut du Cerveau - ICM, Inserm U1127, CNRS UMR 7225, AP-HP - Hôpital Pitié-Salpêtrière, Paris, France Reference Centre for Rare or Early Dementias, IM2A, Départment de Neurologie, AP-HP - Hôpital Pitié-Salpêtrière, Paris, France Inserm U 1127, CNRS UMR 7225, Sorbonne Université, Paris Brain Institute–Institut du Cerveau (ICM), FRONTlab, Paris, France PubMed articlesGoogle scholar articles
  • Florence Pasquier Univ Lille, Inserm U1171, CHU Lille, DistAlz, LiCEND, CNR-MAJ, Lille, France PubMed articlesGoogle scholar articles
  • Philippe Couratier CMRR Service de Neurologie, CHU de Limoges, Limoges, France PubMed articlesGoogle scholar articles
  • Sophie Auriacombe CMRR Nouvelle Aquitaine, Institut des Maladies Neurodégénératives Clinique (IMNc), CHU de Bordeaux Hôpital Pellegrin, Bordeaux, France PubMed articlesGoogle scholar articles
  • Mathilde Sauvée CMRR de l’Arc Alpin, POLE PRéNeLE, CHU Grenoble Alpes, Grenoble, France PubMed articlesGoogle scholar articles
  • Claire Boutoleau-Bretonnière CHU Nantes, Inserm CIC04, Department of Neurology, Centre Mémoire de Ressources et Recherche, Nantes, France PubMed articlesGoogle scholar articles
  • Jérémie Pariente Department of Neurology, Toulouse University Hospital, Toulouse, France Toulouse NeuroImaging Centre (ToNIC), Inserm, UPS, University of Toulouse, Toulouse, France PubMed articlesGoogle scholar articles
  • Mira Didic APHM, Timone, Service de Neurologie et Neuropsychologie, Hôpital Timone Adultes, Marseille, France Institut de Neurosciences des Systèmes (INS), Aix-Marseille University, Inserm, Marseille, France PubMed articlesGoogle scholar articles
  • Didier Hannequin Department of Neurology and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, Normandie University, UNIROUEN, Inserm U1245 and Rouen University Hospital, Rouen, France PubMed articlesGoogle scholar articles
  • David Wallon Department of Neurology and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, Normandie University, UNIROUEN, Inserm U1245 and Rouen University Hospital, Rouen, France PubMed articlesGoogle scholar articles
  • the French Research Network on FTD/FTD-ALS
    Google scholar articles
  • the PREV-DEMALS and Predict-PGRN study groups
    Google scholar articles
  • Olivier Colliot Sorbonne Université, Paris Brain Institute - Institut du Cerveau - ICM, Inserm U1127, CNRS UMR 7225, AP-HP - Hôpital Pitié-Salpêtrière, Paris, France Aramis Project Team, Inria Paris Research Centre, Paris, France PubMed articlesGoogle scholar articles
  • Bruno Dubois Sorbonne Université, Paris Brain Institute - Institut du Cerveau - ICM, Inserm U1127, CNRS UMR 7225, AP-HP - Hôpital Pitié-Salpêtrière, Paris, France Reference Centre for Rare or Early Dementias, IM2A, Départment de Neurologie, AP-HP - Hôpital Pitié-Salpêtrière, Paris, France Inserm U 1127, CNRS UMR 7225, Sorbonne Université, Paris Brain Institute–Institut du Cerveau (ICM), FRONTlab, Paris, France PubMed articlesGoogle scholar articles
  • Alexis Brice Sorbonne Université, Paris Brain Institute - Institut du Cerveau - ICM, Inserm U1127, CNRS UMR 7225, AP-HP - Hôpital Pitié-Salpêtrière, Paris, France PubMed articlesGoogle scholar articles
  • Richard Levy Sorbonne Université, Paris Brain Institute - Institut du Cerveau - ICM, Inserm U1127, CNRS UMR 7225, AP-HP - Hôpital Pitié-Salpêtrière, Paris, France Reference Centre for Rare or Early Dementias, IM2A, Départment de Neurologie, AP-HP - Hôpital Pitié-Salpêtrière, Paris, France Inserm U 1127, CNRS UMR 7225, Sorbonne Université, Paris Brain Institute–Institut du Cerveau (ICM), FRONTlab, Paris, France PubMed articlesGoogle scholar articles
  • Sylvie Forlani Sorbonne Université, Paris Brain Institute - Institut du Cerveau - ICM, Inserm U1127, CNRS UMR 7225, AP-HP - Hôpital Pitié-Salpêtrière, Paris, France PubMed articlesGoogle scholar articles
  • Isabelle Le Ber Sorbonne Université, Paris Brain Institute - Institut du Cerveau - ICM, Inserm U1127, CNRS UMR 7225, AP-HP - Hôpital Pitié-Salpêtrière, Paris, France Reference Centre for Rare or Early Dementias, IM2A, Départment de Neurologie, AP-HP - Hôpital Pitié-Salpêtrière, Paris, France Inserm U 1127, CNRS UMR 7225, Sorbonne Université, Paris Brain Institute–Institut du Cerveau (ICM), FRONTlab, Paris, France PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Isabelle Le Ber, Sorbonne Université, Paris Brain Institute–Institut du Cerveau (ICM), Inserm U1127, CNRS UMR 7225; Reference Centre for Rare or Early Dementias, IM2A, Département de Neurologie, Hopital Universitaire Pitie Salpetriere, Paris, France; isabelle.leber{at}upmc.fr
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Citation

Saracino D, Dorgham K, Camuzat A, et al
Plasma NfL levels and longitudinal change rates in C9orf72 and GRN-associated diseases: from tailored references to clinical applications
Journal of Neurology, Neurosurgery & Psychiatry 2021;92:1278-1288.

Publication history

  • Received April 19, 2021
  • Accepted July 13, 2021
  • First published August 4, 2021.
Online issue publication 
January 07, 2022

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.