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Correspondence
Toluene induced postural tremor
  1. DIRK DELEU
  1. Departments of Clinical Pharmacology and Neurology, College of Medicine, Sultan Qaboos University, PO Box 35, Al Khod, Muscat-123, Sultanate of Oman
  2. Drug Information Services, Hospital Pharmacy
  1. Dr Dirk Deleu, College of Medicine, PO Box 35, Sultan Qaboos University, Al-Khod, Muscat-123, Sultanate of Oman email deleu{at}omantel.net.om
  1. YOLANDE HANSSENS
  1. Departments of Clinical Pharmacology and Neurology, College of Medicine, Sultan Qaboos University, PO Box 35, Al Khod, Muscat-123, Sultanate of Oman
  2. Drug Information Services, Hospital Pharmacy
  1. Dr Dirk Deleu, College of Medicine, PO Box 35, Sultan Qaboos University, Al-Khod, Muscat-123, Sultanate of Oman email deleu{at}omantel.net.om

https://doi.org/10.1136/jnnp.68.1.118

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    We read with interest the article by Miyagiet al 1 and comment on the medical treatment of toluene induced tremor. Microdialysis experiments in rats have shown that inhalation of toluene increases extracellular γ-aminobutyric acid (GABA) concentrations within the cerebellar cortex2 which probably explains why GABA agonists including benzodiazepines (for example, clonazepam) are not very effective in toluene induced tremor and ataxia. Rat experiments also showed a 50% reduction in …

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