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Anti-titin antibodies are not associated with a specific thymoma histology
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After the first description of antibodies to titin in patients with thymoma associated myasthenia gravis in 1990, this finding was independently confirmed and the main immunogenic region of titin (mgt30) identified.1 This 30 kDa part of titin is now also commercially available as antigen for detecting anti-titin antibodies. Furthermore, in a series of 276 patients, we could confirm the clinical usefulness of measuring anti-titin antibodies for predicting the presence of a thymic epithelial tumour in patients with myasthenia gravis that was significantly better than the …
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Competing interests: none declared.