Re:Reply to "Sleep disorders in Charcot-Marie-Tooth disease type 1".
MatthiasBoentert, Senior Physician,
, ,
Other Contributors:
April 13, 2016
We are grateful for the notificiation that restless legs syndrome
(RLS) has been found to be associated also with demyelinating neuropathies
other than CMT type 1. It would be interesting to further investigate the
putative association between RLS and sensory symptoms in the conditions Dr
Luigetti and Dr Della Marca mention in the response to our article. With
regard to the prevalence of RLS in patients with CMT1 we would like to
state that we found a prevalence of 40.9% in the study population (not
50%). In our study, diagnosis of RLS was only confirmed when all four
diagnostic criteria for RLS (proposed by Allen et al.)were met. Thus, over
-estimation of RLS frequency cannot be ascribed to diagnostic inaccuracy.
However, we already mentioned in our article that RLS prevalence was
unexpectedly high in our study which may be due to a selection of patients
with RLS during patient recruitment.
We are grateful for the notificiation that restless legs syndrome (RLS) has been found to be associated also with demyelinating neuropathies other than CMT type 1. It would be interesting to further investigate the putative association between RLS and sensory symptoms in the conditions Dr Luigetti and Dr Della Marca mention in the response to our article. With regard to the prevalence of RLS in patients with CMT1 we would like to state that we found a prevalence of 40.9% in the study population (not 50%). In our study, diagnosis of RLS was only confirmed when all four diagnostic criteria for RLS (proposed by Allen et al.)were met. Thus, over -estimation of RLS frequency cannot be ascribed to diagnostic inaccuracy. However, we already mentioned in our article that RLS prevalence was unexpectedly high in our study which may be due to a selection of patients with RLS during patient recruitment.
Conflict of Interest:
None declared