Re:Reply to "Sleep disorders in Charcot-Marie-Tooth disease type 1".

Matthias Boentert, Senior Physician,

Other Contributors:

June 10, 2013

We are grateful for the notificiation that restless legs syndrome (RLS) has been found to be associated also with demyelinating neuropathies other than CMT type 1. It would be interesting to further investigate the putative association between RLS and sensory symptoms in the conditions Dr Luigetti and Dr Della Marca mention in the response to our article. With regard to the prevalence of RLS in patients with CMT1 we would like to state that we found a prevalence of 40.9% in the study population (not 50%). In our study, diagnosis of RLS was only confirmed when all four diagnostic criteria for RLS (proposed by Allen et al.)were met. Thus, over -estimation of RLS frequency cannot be ascribed to diagnostic inaccuracy. However, we already mentioned in our article that RLS prevalence was unexpectedly high in our study which may be due to a selection of patients with RLS during patient recruitment.

Conflict of Interest:

None declared

Conflict of Interest

None declared