eLetters

171 e-Letters

published between 2007 and 2010

  • Re:Possibility of epigenetic events in the pathogenesis of ALS
    Ammar Al-Chalabi

    Dear Editor,

    We agree that genetic studies have so far explained only a small fraction of the heritability of ALS (1,2), and this is true in many other diseases as well (3). Epigenetic factors are almost certainly part of the answer, but there are also several other possibilities. We are only just developing the tools to look for disease-associated rare variants on a large scale. In addition, we do not understa...

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  • Possibility of epigenetic events in the pathogenesis of ALS
    Heikki Savolainen

    Dear Editor,

    The twin studies show conclusively the limits of classical genetics in the studies of the etiology and pathogenesis of the ALS (1).

    It has been suggested that a susceptibility or familial factor could play a role. In this case, they may be mediated by epigenetic mechanisms which control the activity and expression of the genome (2).

    The incorrectly coded polypeptides could lead to...

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  • Possibility of epigenetic events in the pathogenesis of ALS
    Heikki Savolainen

    Dear Editor,

    The twin studies show conclusively the limits of classical genetics in the studies of the etiology and pathogenesis of the ALS (1).

    It has been suggested that a susceptibility or familial factor could play a role. In this case, they may be mediated by epigenetic mechanisms which control the activity and expression of the genome (2).

    The incorrectly coded polypeptides could lead to...

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  • Is freezing in Parkinson's disease a visual-motor hyperfunction?
    Dorothy Cowie

    Dear Editor,

    The article 'Disorders of Visual Perception' (ffytche, Blom & Catani, JNNP 2010;81:1280-1287) presents an interesting new classification of disorders of visual perception. It describes a wide range of disorders whose sources are cortical or subcortical rather than due to diseases of the eye. Each is classified as a disorder of one brain region (topological disorders) or of connectivity between re...

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  • Aortic arch and ulcerative plaques
    SABINO G ECHEBARRIA MENDIETA

    Recent developments by Harloff ( 2008 ) describibg high risk plaques detected by TOE and MRI in aortic arch , and cryptogenic stroke , depicted certain characteristics ( > 4 mm thickness or presence of ulcerations or mobile components ) . Considering associated conditions , such aortic thrombi are defined as laminated deposition along the initial surface with variable echogenicity with or without mobile lesions... Tou...

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  • Perceptions of patients, neurologists, and members of multidisciplinary teams. A collaborative study between the Motor Neurone Disease Association and the Peninsula MND network.
    Stuart Weatherby

    M.Tanaka Gutiez, L.Jarrett, B. Nevin, J. Stewart and S. Weatherby

    Sir, A recent study published in the JNNP suggests that quality of life for people living with motor neuron disease (PwMND) is influenced by their perceptions of social support[1].

    We would like to share the results of a study carried out jointly with the Motor Neurone Disease Association (MNDA) and the peninsula MND network, which fu...

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  • In Re: Recurrent stroke after cervical artery dissection
    Joshua Z Willey

    I read the article by Weimar, et al with interest. The authors describe the largest case series to date of cervico-cephalic dissection in a multi-hospital registry in Germany. I found the findings on the risk of recurrent stroke being lower in the anti-coagulation group, similar in internal carotid versus vertebral artery, and higher in the occlusion versus stenosis group telling. The overall risk of recurrent stroke bein...

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  • MS may be a progressive disease occurring independently of exacerbations and remissions.
    Steven R Brenner

    I read the article on disability progression in patients with multiple sclerosis whether treated with interferon or not with interest(1)

    Although may of the placebo treated patients probably were treated with some form of immunomodulatory treatment after the study period, it certainly raises the question of whether neuronal progression in multiple sclerosis is due to accumulated deficits from exacerbations and re...

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  • Posterior Reversible Encephalopathy Syndrome: Has the time come for a change in name?
    Sandeep S. Rana
    Re: Spinal cord involvement in posterior reversible encephalopathy syndrome. B Lapuyade, I Sibon, S Jeanin, V Dousset jnnp 2009;80:35 doi:10.1136/jnnp.2008.154781 Dear Editor, We read with great interest the article, "Spinal cord involvement in posterior reversible encephalopathy syndrome" published by B Lapuyade et al (JNNP January 2009). We recently treated a patient with similar presentation. She was 22 year old female who pre...
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  • Biopsy findings in Parry Romberg Syndrome / Scleroderma 'en coup de sabre'
    Jon Stone

    Moseley et al report an interesting case of Parry Romberg syndrome with contralateral MRI changes. A similar case of Scleroderma 'en coup de sabre' was published previously in JNNP. This case also had a brain biopsy of a contralateral thalamic lesion and similar perivascular inflammatory changes were seen [1].

    Reports of neuropathology remain rare in these overlap conditions. This additional report is useful in...

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