154 e-Letters

published between 2008 and 2011

  • Were Babylonians Self-Conscious?
    Andrea E. Cavanna

    Reynolds and Wilson's article on obsessive compulsive disorder and psychopathic behaviour in Babylon gives us unprecedented insights into how these psychiatric disorders were identified and - to some extent - conceptualised by an ancient civilization. Surprisingly, the Babylonian descriptions are accurate and modern, and thoroughly objective. As noticed by the Authors, this objectivity is one of the most interesting aspect...

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  • Response to the letter: Treatment of paroxysmal sympathetic storm with labetalol
    Agbolahan A Sofela
    Dear Editor, I read with great interest the article by Do D et al. regarding the treatment of paroxysmal sympathetic storm with labetalol. I'll lilke to thank the authors for such a concise and clinically relevant piece on not only the typical presentation and early recognition of sympathetic storming, but also an evidence based (the case report mentioned in the original letter) method for managing these patients. This is a very e...
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  • Focal onset of ALS
    Andrew Eisen

    Focal onset of ALS is attractive; it superficially mirrors what is encountered clinically, initial weakness in an arm, leg or bulbar muscles and is an explanation for phenotypic variation in terms of site of onset and rate of progression (Ravits and La Spada 2009). I congratulate Fujimura-Kimono and colleagues in their efforts to define patterns of spread through the ALS motor system and finding that the interval between...

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  • Re:Anti-A? autoantibodies in cerebral amyloid angiopathy related inflammation: a role for pathogenesis?
    P. Alan Barber

    We thank Drs DiFrancesco et al for their comments on our recent paper in which we proposed diagnostic criteria for cerebral amyloid related inflammation (CAA-I). The report by this group of an increase in anti- amyloid beta autoantibodies in a 68 year old man with probable CAA-I is of interest and may well help further our understanding of the pathogenesis of CAA-I. However, we agree that this finding must be confirmed in a...

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  • Anti-A? autoantibodies in cerebral amyloid angiopathy related inflammation: a role for pathogenesis?
    Jacopo C. DiFrancesco
    In their recent paper Chung and colleagues[1] describe 3 cases of cerebral amyloid angiopathy related inflammation (CAA-I) all confirmed by brain biopsy and review the scientific literature, proposing the criteria for probable and definite diagnosis. CAA-I is a rare and treatable encephalopathy affecting a subgroup of CAA patients, in which a predisposing condition is represented by the APOE ?4/?4 genotype in the majority of pati...
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  • The symptom of low mood in the prodromal stage of mild cognitive impairment and dementia
    Dr Osama Hammer MBBch.,MSc.,MRCPsych

    Dementia and depression are frequently comorbid among older adult patients. Depression is related to cognitive decrement and can even represent the first signs of a neurodegenerative process. It can be difficult to distinguish depressed patients exhibiting the first signs of dementia from those whose cognition will improve with treatment. Studies from the neuropsychological reported that there is relationship between de...

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  • Ataxin-2 needs to be considered in TDP-43 positive patients with PSP-like parkinsonism and motor neuron disease
    Christos Proukakis


    Espay and colleagues report a detailed clinical and pathological study of two unrelated individuals with rapidly progressive atypical parkinsonism (similar to progressive supranuclear palsy, PSP), and additional frontotemporal and motor neuron involvement, in whom TDP-43 inclusion pathology was demonstrated. (1) Sequencing of PGRN and TARDBP gene coding regions was negative, and therefore no genetic cause...

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  • Biocomposites Ltd response
    Simon Fitzer

    We read with interest the article "Dangers of bone graft substitutes: lessons from using Genex" (Saadoun, MacDonald, Bell and Papadopoulos, JNNP published online March 8, 2011), notably as it purported the potential for Genex putty to "cause soft tissue inflammation and destruction".

    All three patients in the article were reported to have wound related adverse reactions. Since initial certification, in excess of 5,0...

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  • A Simple Non-Invasive Method of Testing Whether High Intrauterine Testosterone Concentrations Are a Cause of Amyotrophic Lateral Sclerosis : A Response to Papers of Vivekananda et al.
    William H James

    Vivekananda et al(1)report that when controlled for sex, cases of sporadic amyotrophic lateral sclerosis (ALS) have a lower mean finger length ratio R [where R = (2D / 4D) and 2D and 4D are the lengths of the 2nd and 4th digits respectively] than healthy controls. These authors interpret their finding as indicating prenatal involvement of high concentrations of intrauterine testosterone, T. However, their interpretation...

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  • Prevention versus treatment of postherpetic neuralgia
    Josephine M.I. Vos

    Amsterdam, 4th May 2011

    Dear dr. Saarto,

    Regarding your Cochrane review "Antidepressants for neuropathic pain" which was published in J Neurol Neurosurg Psychiatry. 2010 Dec;81(12):1372 -3, we would like to point out an inconsistency.

    Our comment refers to the statement made on page 11: : "Six placebo- controlled studies were found in postherpetic neuralgia. All demonstrated superiority of a...

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