eLetters

118 e-Letters

published between 2010 and 2013

  • C9ORF72 in dementia with Lewy bodies
    David M Mann

    INTRODUCTION Recent studies have shown that a large hexanucleotide expansion in C9ORF72 is the most common cause of inherited Frontotemporal Lobar Degeneration (FTLD) and Motor Neurone Disease (MND).1 In pathological terms, expansion carriers show a distinctive molecular signature within the dentate gyrus granule cells and CA4 pyramidal cells of the hippocampus and granule cells of the cerebellum characterised by TDP-43-ne...

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  • Does clinical evidence for lower motor neuron dysfunction support prion-like spreading in ALS?
    Ken Nakamura

    In a recent, impressive article, Teruhiko Sekiguchi et al. (1) hypothesize that misfolded proteins accumulating in some neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), can cause aggregation of their native counterparts through a mechanism similar to the infectious prion protein's induction of a pathogenic conformation onto its normal cellular isoform....

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  • Setting the Gold Standard
    Sallie A Baxendale

    Dear Sirs,

    We read the above study with interest and appreciated the thorough analysis. Whilst the authors acknowledge in their discussion that the Wada test is a 'silver standard', they nevertheless conclude that the Wada test is warranted when fMRI fails to show clear left lateralisation. We would make the following points:

    1. The true "gold standard" for language dominance tests is prediction of outc...

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  • Re:Trigeminalepsy.
    Carlos Miro

    We celebrate the excitement shown by Unterberger and Bauer to our contribution on trigeminalepsy, since they give us the chance to include some technical data which were considered of limited interest for clinicians. Figure 1 in our original paper shows a 4.20 seconds frame from a conventional 32-channel video-EEG register filtered within 0.5-70 Hz. [1]

    We chose figure 1 because it unequivocally shows interictal...

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  • Trigeminalepsy.
    Iris Unterberger

    Sirs, We read with interest and some kind of excitement the contribution of Mir? and Ortiz about "Trigeminalepsy" (1). We would like to concentrate our comments on "Figure 1 Video-EEG trace revealing spike discharges ..." No technical details like montage, filters and time frame are indicated. Therefore, a post hoc interpretation includes uncertainities. However, a change of dominant activities after the arrow ("touch of...

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  • A CASE OF RECURRENT BICKERSTAFF BRAINSTEM ENCEPHALITIS
    Josanne Aquilina

    We read with great interest the review by Dr Shahrizaila and Prof Yuki on Bickerstaff brainstem encephalitis (BBE) and Fisher syndrome (FS) (1) and would like to refer in particular to the section about recurrent illnesses. As stated, FS and BBE are typically monophasic and recurrent episodes are rare. Although recurrent episodes have been described in the literature, after a thorough literature search, only one clear do...

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  • Cerebral amyloid angiopathy-scoring methods
    Kurt A Jellinger

    In their recent meta-analysis of genetics of cerebral amyloid angiopathy (CAA), Rannikmae et al,[1] focusing on the association between APOEe4 and sporadic CAA, stated that there is no widely accepted standardised histopathological grading system for CAA. Although this is true, several methods are currently used to describe the severity of CAA in postmortem brain,[2, 3] and recently a semiquantitative scoring method has...

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  • Re:The role of dopamine transporter single photon emission CT (DaT-SPECT) in the diagnosis of drug-induced Parkinsonism.
    Igor Grachev

    We thank Dr McKinley for his correspondence on our paper entitled "Clinical utility of dopamine transporter single photon emission computed tomography (DaTspect) with [123I] ioflupane in diagnosis of parkinsonian syndromes".

    Although suspected drug-induced parkinsonism (DIP) was not a direct focus of our review, we included DIP cases and discussed them as being either suspected/uncertain parkinsonian syndromes...

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  • Re: DISCORDANT EFFECTS ON ANXIETY AND DEPRESSION OF MEDITERRANEAN DIET AND OF PHYSICAL ACTIVITY ENHANCEMENT
    Miguel Martinez-Gonzalez

    We appreciate the comments by Trovato FM et al in their Letter to the Editor regarding our recently published trial on Mediterranean Diet (MedDiet) and cognition (The PREDIMED-NAVARRA trial) [1]. The PREDIMED- NAVARRA trial found a favorable effect of MedDiet on cognitive function [1]. This protection was independent of other confounders including mood disorders and physical activity. In a previous report, Trovato et al s...

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  • DISCORDANT EFFECTS ON ANXIETY AND DEPRESSION OF MEDITERRANEAN DIET AND OF PHYSICAL ACTIVITY ENHANCEMENT
    Guglielmo Trovato

    We read with a great interest the article of Mart?nez-Lapiscina et al.[1] which elegantly demonstrate how an intervention with Mediterranean Diets enhanced with either extra-virgin olive oil or nuts supplements appears to improve cognition compared with a generic low-fat diet. Concurrently, elsewhere, the article in "Epidemiology" by Samieri et al.[2] casts doubt on the available evidence that Adherence to a Mediterran...

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