eLetters

190 e-Letters

published between 2006 and 2009

  • Epstein-Barr virus may cause Multiple Sclerosis through involvement of the venous system.
    Steven R Brenner

    Dear Editor,

    I read the article by Zivadinov (1) with reference to the association of Epstein-Barr virus (EBV) to gray matter atrophy in multiple sclerosis (MS) patients.

    Accumulation of EBV infected B cells in meninges and perivascular regions of MS lesions in 21 or 22 patients with MS (2) was noted as well, indicating direct involvement of the brain and perivascular spaces by EBV in MS patients.....

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  • Are intravenous immunoglobulines truly beneficial in diabetic patients with CIDP?
    Josef Finsterer

    Dear Editor,

    With interest we read the article by Jann et al. on 16 patients with diabetic mellitus (DM) who also developed chronic inflammatory demyelinating polyneuropathy (CIDP) [1]. The study raises concerns.

    Though it is stated that CIDP was diagnosed according to the criteria of the American Academy of Neurology (AAN) [2,3], the authors define partial conduction block and abnormal temporal dispers...

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  • Re: Increasing prevalence and incidence of multiple sclerosis in South East Wales
    Klaus J. Lauer

    Dear Editor,

    In their recent publication of the updated prevalence and incidence of multiple sclerosis (MS) in South East Wales, Hirst et al. reported a significant increase of the MS prevalence from 101 / 105 to 146 / 105 (definite and probable MS) in the last twenty years (1). Although the rate is signigicantly higher at present and the MS incidence had increased continuously since the first survey, one might...

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  • Long-term effects of the concomitant use of memantine with cholinesterase inhibition in AD: a Respon
    Bhavani S Bagepally

    Dear Editor,

    It is important to note more than half of the patients of dementia are not started on any of anti-dementia drugs at first evaluation (866- 56.4%) and nearly 40% of patients not received even after one year of follow up.

    Even though there is not much difference in clinical condition, cognitive status behavioral and psychological symptoms between the patents with and without any treatment (table 2...

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  • Re: Does vitamin D status effect interact with smoking habits re cognition?
    David M Lee

    Dear Editor,

    In response to B.Boucher's interesting question of whether we found smoking to be associated with worsened cognitive performance at higher serum 25-(OH)D concentrations than would be the case in non-smokers...

    1. Although smokers had lower PTH levels than non-smokers (ca. 0.1 SD), this difference was non-signifcant following adjustment for age.

    2. We found no evidence of a 25(OH)D...

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  • MS appears to be related to venous flow abnormality of the brain with secondary brain autoimmunity
    Steven R Brenner

    Dear Editor,

    I read the article by Zomboni (1) with interest, with respect to the interaction of the cerebral venous system and central nervous system in development of multiple sclerosis (MS).

    An interaction between the central nervous system and venous system has been observed previously in MS lesions by F. A Schelling (2) who initially observed “striking widening of the main venous passageways in t...

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  • Role of Ultrasound examination of urinary tract in monitoring people with bladder symptoms due to MS
    Sivaraman KP Nair

    Dear Editor,

    Congratulations to Fowler et al on publishing UK consensus on the bladder management in Multiple sclerosis1. This timely publication will be welcomed by all the health care professionals dealing with patients with MS.

    The common cause of bladder dysfunction in MS is lesions in the spinal cord. The pathogenesis of bladder symptoms in MS are similar to that of people with incomplete Spinal...

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  • Electrical stimulation for stroke
    Rizaldy Pinzon

    Dear Editor,

    This study suggest that electrical somatosensory stimulation may improve motor function of the affected hand after stroke. There are very few therapeutic options for the treatment of motor disabilities from stroke. Motor training results in use-dependent plasticity, thought to underlie recovery of motor function after cortical lesions. Use-dependent plasticity (UDP) is instrumental in motor learnin...

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  • Intravenous levetiracetam in the treatment of refractory status epilepticus: a word of caution
    Nitin K Sethi

    Dear Editor,

    I read with interest the article by Moddel et al. about the efficacy of intravenous levetiracetam in the treatment of refractory status epilepticus 1. Their retrospective chart review of 36 patients treated with intravenous levetiracetam suggests that it may be a safe and efficacious treatment for refractory status epilepticus and adds to the existing literature for this off label use. I commend th...

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  • Does vitamin D status effect interact with smoking habits re cognition?
    Barbara J Boucher

    Dear Editor,

    This interesting paper adjusts for smoking and smoking reduces circulating parathyroid hormone concentration; this effect would be expected to reduce vitamin D activation(1). One might, therefore, expect smoking to be associated with worsened cognitive performance at a higher serum 25-(OH)D concentration than would be the case in non-smokers. Can the authors tell us, therefore, whether there is any...

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