154 e-Letters

published between 2008 and 2011

  • Cancer Risk in Multiple Sclerosis
    Edward J. Needham

    We were interested to read the meta-analysis by Handel and Ramagopalan,1 summarising the body of evidence which points towards a reduction of cancer risk in patients with multiple sclerosis.

    We performed a study investigating the same question, using our hospital's clinical coding database to compare the frequency of cancer in all multiple sclerosis patients admitted over a 10 year period (1090 patients), with...

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  • Anatomical stenosis of the internal jugular veins : supportive evidence of chronic cerebrospinal venous insufficiency ?
    Andrea Baiocchini

    We write in relation to the editorial commentary from Khan et Tselis (1) who rightly suggest caution to consider chronic cerebrospinal venous insufficiency (CCSVI) as a pathological entity and cast serious doubt on its relevance to multiple sclerosis (MS); they forecast properly designed studies to investigate the relevance of CCSVI to MS, in order to carry out interventional procedures. The absence of extracranial venous...

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  • Recovery or maintenace?
    Birgitta Langhammer

    We read with interest the meta-analysis with the focus on physiotherapy interventions late after stroke and we would like to thank the authors for their effort to shed light on this subject. Interventions late after stroke are an important area of rehabilitation that has been neglected. There most certainly is a need for rehabilitation and exercise tailored for stroke survivors late after onset. As the authors point out...

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  • The clinico-radiological spectrum of cortical convexity subarachnoid haemorrhage
    Cesar Tabernero

    We have read with great interest the work of Dhollander et al. [1] and express our congratulation for their wonderful work, but we would like to add some considerations. The authors describe two patients presenting clinically transient neurological deficit and radiologically with a focal cortical subarachnoid haemorrhage in the brain CT and multifocal cortical siderosis in brain MR. They compare their patients with the clas...

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  • Disease progression or deterioration?
    G Stern

    Most authorities, from Samuel Johnson's to the current Oxford University Dictionary, define "progression" as a change for the better stemming from the Latin "prograde" to improve continuously and "deterioration" as a change for the worse (Latin "deteriore"). Yet most neurological journals appear to accept "disease progression" (as in secondary progressive multiple sclerosis and progressive supranuclear palsy) to indicat...

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  • Anaplastic oligodendroglial tumors: Do gray matter involvement correlate with 1p19q codeletion?
    Gentian Kaloshi

    Gentian Kaloshi, Mentor Petrela

    In their recently published article, Kim et al (1) describe the imaging characteristics of anaplastic oligodendroglioma and anaplastic oligoastrocytoma (AO/AOAs) in an effort to correlate them with molecular alterations. They try to conclude that high-grade oligodendroglial tumors (AO/AOAs) share a similar relationship between radiological characteristics and molecular signatures...

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  • CSF biomarkers in the differential diagnosis of Alzheimer's disease and frontal variant of frontotemporal dementia
    Massimo Franceschi

    Dear Sirs,

    we read with great interest the paper by Cruz de Souza et al (1) , since we conducted a similar clinical experience, with slightly different findings In order to achieve data regarding the usability and reliability in the "real world" of CSF biomarkers in the early differentiation of Alzheimer Disease (AD) from frontal variant of Fronto-Temporal Dementia (fvFTD) , we designed a prospective study in w...

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  • Evidence seriously flawed due to survival-related biases and confounding
    Igor Karp

    We read with great interest a recent article by D'hooghe et al. (1) on long-term effects of childbirth on MS. Unfortunately, the study appears to have been subject to important biases (in addition to those discussed by the authors themselves, including, notably, confounding).

    The first bias - namely, the left-truncation bias (2) - has to do with the fact that to be included in the analyses, patients had to be "...

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  • Elevation of Anti-MuSK antibody in a case with oculopharyngeal myopathy showing chondroitin sulfate deficiency
    Ichiro Yabe

    In 2002, we reported in this journal a patient with corticosteroid- responsive oculopharyngeal myopathy and an absence of chondroitin sulfate in muscle biopsies [1]. In recent years, the patient was found to have antibodies against muscle-specific kinase (MuSK). This female patient presented in 1993 at the age of 42 years with proximal muscle weakness in the neck and difficulty in swallowing, followed by blepharoptosis an...

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  • Early therapeutic intervention for hyponatremia after subarachnoid haemorrhage
    Satoru Takeuchi

    We read with interest the recent study by Zheng et al.[1] The authors assessed the predictive value of hyponatremia for poor outcome or cerebral infarction in high-grade patients after aneurysmal subarachnoid haemorrhage (aSAH), and concluded that hyponatremia did not predict poor outcome in all-grade aSAH patients, whereas late-onset (3 days after aSAH) hyponatremia in high-grade aSAH patients was associated with cerebral...

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