92 e-Letters

published between 2013 and 2016

  • Meta-analysis by Xu et al. suffers from critical errors
    Evangelos Evangelou

    The meta-analysis by Xu et al is a valiant effort to map the evidence for modifiable risk factors of Alzheimer's disease (AD) (1). We acknowledge this huge effort, however, we have serious concerns regarding the systematic appraisal and the synthesis of the available data.

    On top of the critique by Drs. Wu and Brayne (e-letter), a comprehensive assessment of the article and its results can reveal critical error...

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  • Re:"Correction to odds ratio"
    Sascha K?pke

    Dear Editor,

    We thank Dr. Solari for pointing out an aspect of possible misunderstanding, but surely not incorrectness. We agree that the reverse odds ratio of 5.63 (95% CI 2.87 to 11.05, p<0.001) would more clearly refer to the odds of achieving informed choice. Still the reported odds ratio of 0.18 (95% CI 0.09 to 0.35, p<0.001) gives exactly the same information and is probably more intuitively underst...

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  • "Correction to odds ratio"
    Alessandra Solari

    I enjoyed reading the paper of Sascha Kopke et al. [1] on the efficacy of an evidence-based information program for people with recently diagnosed multiple sclerosis. I noticed, however that the odds ratio (OR) for the primary endpoint (achieving 'informed choice') is incorrect, both in the Abstract and in the Results.

    Abstract: 'For the primary endpoint, a significant difference was shown with 50 of 85 (59%) pa...

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  • Thiamine compounds in humans
    Marco Poloni

    I have some comments concerning the report by S. Jesse, D.R. Thal and A.C. Ludolph, recently published in JNNP September 15 2015, pag. 1166-1168 "Thiamine deficiency in Amyotrophic Lateral Sclerosis". In a research dated 1981 Rindi et al. showed that in 12 CSF samples obtained from different healthy subjects, without any clinical disorder involving thiamin status, the only thiamin compounds detected after electrophoretic...

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  • Cholinesterase inhibitors and falls in Parkinson's disease
    Martijn L.T.M. Muller

    We read with great interest the paper by Pagano et al. who conducted a systematic review of prospective, randomised placebo-controlled trials (RCT), in order to assess the efficacy and safety of cholinesterase inhibitors (ChIs) in patients with Parkinson's disease (PD).[1] They concluded that ChIs are effective in the treatment of cognitive impairment in patients with PD. We concur with the authors' nuanced conclusion in...

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  • Comments on "Meta-analysis of modifiable risk factors for Alzheimer's disease"
    Yu-Tzu Wu

    The meta-analysis by Xu et al., (2015)[1] reviews over 300 papers and identified 93 modifiable risk factors for Alzheimer's disease. Among these risk factors, population attributable risks (PAR) of nine important factors were estimated to contribute to up to 66% of Alzheimer's disease cases globally. We acknowledge the great effort of this massive review but there are some substantial analytical issues which should be highl...

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  • Treatment of neuropsychiatric syndromes in Alzheimer's disease (AD): In search of evidence?
    Amir A. Sepehry

    We read with interest the recent systematic review and meta-analysis, "Pharmacological treat-ment of neuropsychiatric symptoms in Alzheimer's disease"(1). By examining the evidence for treating heterogeneous range of neuropsychiatric syndromes in persons with Alzheimer's disease (AD), this study found favorable results for the use of cholinesterase inhibitors (ChEIs) and atyp-ical antipsychotics albeit with risk of side ef...

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  • Hazards of formaldehyde in the workplace.
    Irene Campbell-Taylor

    The article by Roberts and colleagues on formaldehyde and ALS, is important for its contribution to job related hazards of formaldehyde exposure. One occupation that would be interesting to examine, is wood working/carpentry using mainly plywood. At the core of its manufacture, is formaldehyde. Plywood for indoor use generally uses urea-formaldehyde glue, which has limited water resistance, while outdoor and marine-grade...

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  • Paralympics and Conversion Disorder - "secondary gain" should not be a reason for exclusion
    Jon Stone

    Anthony David's article on Paralympics and conversion disorder opens an important and useful debate about the legitimacy of physical disability when related to a functional (psychogenic) disorder and the extent to which patients with these disorders should have access to the normal rights of a disabled person(3). If functional disorders, and to be clear we are talking here specifically about functional limb weakness, are...

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  • HIV and lower risk of multiple sclerosis: protective or subjugating effect?
    Tatiana Koudriavtseva

    Dear Sirs, Gold and colleagues recently found a significantly decreased risk of developing multiple sclerosis (MS) after the onset of HIV infection in a large cohort of national linked data set of English Hospital Episode Statistics.(1) The possible causes of this negative association have been hypothesized to be immunodeficiency and antiretroviral treatment (ART) as MS is usually treated with immunosuppressive drugs and...

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