118 e-Letters

published between 2010 and 2013

  • Re:Metabolic syndrome and the dementias: a link between Alzheimer disease and vascular dementia?
    Vincenzo Solfrizzi

    Metabolic Syndrome and Alzheimer's Disease: Contrasting Epidemiological Evidence and Possible Underlying Mechanisms

    We thank Giannopoulos and colleagues for their interesting Letter. At present, cumulative evidence suggested that metabolic syndrome (MetS), a constellation of interrelated metabolic derangements increasing the risk of cerebrovascular disease (CVD) and diabetes, has been shown to be in...

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  • Re:DAT-SPECT. All that glitters is not gold.
    Eduardo Tolosa
    We wish to thank Dr. Morrish for his comments to our review. He argues in his letter that for diagnostic purposes a technique needs to be sensitive to the disease and reproducible and that DAT-SPECT unfortunately falls down on each. Sensitivity is poor, he says, since DAT-SPECT imaging has been found to be normal in about 5 to 15% of individuals with parkinsonism. Such individuals ( SWEDDs ("scans without evidence of dopaminergic...
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  • DAT-SPECT. All that glitters is not gold.
    Paul K Morrish

    Kagi and colleagues (1) provide a review but not a critique of a controversial technique. For a technique to have diagnostic utility it needs sensitivity to the disease and reproducibility; DAT-SPECT unfortunately falls down on each. The review describes the test as around 100% sensitive as a diagnostic tool in detecting PD. The authors conclude that the normal scans in 5-15% of patients with de-novo PD are normal becau...

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  • Metabolic syndrome and the dementias: a link between Alzheimer disease and vascular dementia?
    Sotirios Giannopoulos

    Metabolic syndrome and the dementias: a link between Alzheimer disease and vascular dementia?

    Sotirios Giannopoulos, Athanassios P. Kyritsis, Maria Kosmidou, Haralampos J. Milionis

    Departments of Neurology & Internal Medicine University of Ioannina School of Medicine, Ioannina, Greece

    Key words: metabolic syndrome; Alzheimer disease; vascular dementia; cerebrovascular disease;


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  • Chronic ataxic neuropathy associated with antibodies to disialogangliosides responsive to Rituximab.
    Chiara Briani

    Dear Editor, we read with great interest the paper by Attarian et al on response to Intravenous immunoglobulin (IVIg) therapy in patients with chronic ataxic neuropathies and anti-GD1b antibodies. We would like to share our experience with a patient with chronic ataxic demyelinating polyneuropathy and antibodies to disialogangliosides who responded to Rituximab therapy. A 69-year-old man presented in August 2006 with sub...

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  • Transcranial magnetic stimulation is a useful diagnostic test in psychogenic paralysis
    Carlo Civardi

    Dear Editor,

    I read with interest the article by Geraldes et al.[1] on the use of transcranial magnetic stimulation (TMS) in psychogenic paralysis. The Authors showed in a young lady with a reversible left body limbs paresis due to conversion disorders (CD), a significant increase of corticomotor threshold and reduction in amplitude of motor evoked potentials (MEP) in the affected side. These changes were resto...

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  • Autosomal dominant axonal Charcot-Marie-Tooth disease associated with dynamin 2 gene mutations
    José Berciano

    I read with interest the excellent review on Charcot-Marie-Tooth disease (CMT) by Reilly and Shy (1). I wish to make a brief comment on CMT associated with dynamin 2 gene mutations. This CMT subtype is currently classified within dominant intermediate CMT type B (DI-CMTB), as electrophysiological study characteristically shows motor conduction velocities in the intermediate range (25-45 m/s). There are, however, three re...

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  • Stroke in Fabry disease frequently occurs in the absence of prior multisystem involvement
    Thierry Zenone

    To the editor: I read with interest the case report recently published in your journal. In this paper, Gregoire and colleagues describe a 24-year-old man with strokes without systemic involvement as the presenting feature of Fabry disease. They conclude that a pure cerebrovascular presentation of Fabry disease without prior multisystem involvement (mainly, cardiomyopathy, skin lesions or renal involvement) has not previo...

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