eLetters

154 e-Letters

published between 2008 and 2011

  • Intravenous levetiracetam for benzodiazepine refractory status epilepticus
    Susanne Knake

    Dear Editor, Dear Dr. Sethi,

    Thank you very much for sending the eLetter regarding our retrospective case "benzodiazepine refractory status epilepticus". We agree, that standard protocols should be used as the rule as long as levetiracetam is not approved for the treatment of status epilepticus (SE) and as long as there is no prospective randomized study demonstrating the efficacy of levetiracetam in SE. In the pa...

    Show More
  • Intravenous levetiracetam for benzodiazepine refractory status epilepticus
    Nitin K Sethi

    Dear Editor

    We read with interest the study by Knake et al. in which they investigated the efficacy and safety of intravenous levetiracetam (ivLEV) for the treatment of status epilepticus 1. Off label usage of LEV is exceedingly common and we would like to commend the authors for providing some data about the efficacy of iv LEV in the treatment of benzodiazepine refractory status epilepticus. All the patients in the...

    Show More
  • Gait assessment in central vestibular pseudoneuritis
    James A Nelson

    Dear Editor

    Cnyrim et al have, in "Bedside differentiation of vestibular neuritis from central 'vestibular pseudoneuritis,'" published an important paper that subjects clinical signs of central vertigo to critical analysis (1).
    I do want to state two concerns I have, that I hope will not detract from a sentiment of gratitude and congratulation.

    First, their study population appears t...

    Show More
  • Microbleeds and risk of hemorrhagic transformation after ischemic stroke
    Monique M.B. Breteler

    Dear Editor

    We read with interest the paper by Lee et al. on the relation between microbleed presence and risk of hemorrhagic transformation after ischemic stroke (J. Neurol. Neurosurg. Psychiatry Jan 10 2008). Based on data from 377 patients with acute atherothrombotic or cardioembolic stroke, the authors conclude that microbleed presence does not predict hemorrhagic transformation after stroke. Thrombolytic treat...

    Show More
  • This may be due to low DHEA.
    James M. Howard

    Dear Editor

    It is my hypothesis that thrombosis/stroke may be due to low DHEA:

    http://www.anthropogeny.com/Thrombosis%20May%20Be%20Caused%20by%20Low%20DHEA.htm

    Many pathological entities associated with thrombosis may be demonstrated to exhibit low DHEA.

    A mother produces DHEA for herself and her fetus. I suggest this split of DHEA may reduce DHEA to very low levels in the mother and tri...

    Show More
  • Sporadic Creutzfeldt-Jakob disease may be due to a slow virus infection
    Steven R Brenner

    Dear Editor

    I read the article by Murray concerning sporadic Creutzfeldt-Jakob disease (CJD) in adolescents with interest (1). Seven cases of sporadic CJD in adolescents in all are described (1) without any history of potential iatrogenic exposure.

    Although an infectious protein or prion is considered to be the cause of the transmissible spongiform encephalopaties such as CJD, bovine spongiform encephal...

    Show More
  • Is an abrupt “cerebral electrical shutdown” during a seizure the mechanism of SUDEP?
    Mark Stewart

    Dear Editor

    We read with great interest the report by McLean and Wimalaratna [1]. They describe the death during ambulatory EEG monitoring of an adult female epileptic patient. A significant finding was an abruptly “flat line” EEG, and the authors suggested that the cerebral electrical shutdown may have been the cause of death.

    We have been studying the autonomic and cardiovascular consequences of sei...

    Show More
  • Incidental findings on MRI and unexpected multiple sclerosis
    Nitin K Sethi
    Dear Editor

    We read with interest the editorial (1) commenting on the paper by Lebrun and colleagues (2). Lebrun and colleagues report a 5 year follow-up of the clinical and MRI findings in patients with subclinical demyelinating lesions fulfilling Barkhof’s criteria on first MRI scan with a normal neurological examination at presentation. None of the 30 patients reported by them had presenting symptoms suggestive of mult...

    Show More
  • Migrainous scintillating scotoma and high-grade ICA stenosis: Why the link to CSD is plausible
    Jens P. Dreier

    Dear Editor

    Leão discovered the spreading negative slow voltage variations in response to either direct current electrical stimulation or bilateral occlusion of the internal carotid artery in 1947. Both neurones and astrocytes depolarise during a spreading negative slow voltage variation, thereby inducing transmembraneous ionic shifts and intracellular oedema [1]. Under anoxia or severe ischaemia, this spreading...

    Show More
  • Hyperacusis : stapedius dystonia?
    Carmela Gerace

    Dear Editor

    Your paper is very interesting. However we consider hyperacusis symptom a possible disorder of stapedius muscle in your patients: have you evaluated this possibility? Assessement of stapedius function with impedancemetry and measurement of its reflex should be useful in neuromuscular disease including myasthenia gravis and facial nerve paralysis. Actually the stapedius reflex consists of a contractio...

    Show More

Pages