eLetters

216 e-Letters

published between 2005 and 2008

  • The utility of the Cambridge Behavioural Inventory in neurodegenerative disease
    Andrew J Larner

    Dear Editor

    Like Dr Wedderburn and colleagues,1 we have investigated the clinical utility of the Cambridge Behavioural Inventory (CBI), but in patients attending memory clinics and not preselected for clinical diagnosis. This pragmatic approach has shown that the difference in CBI global score (possible range 0-324) between patients diagnosed with dementia (range 20-239, mean 99.3 +/- 54.0) and without dementia...

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  • Successful treatment of HIV-associated cerebral vasculopathy with HAART
    Nicholas J Cutfield

    Dear Editor

    In response to whether an HIV-associated vasculopathy may be reversible [1], we describe a man with severe cognitive impairment due to an isolated HIV-associated cerebral vasculopathy, likely to be a vasculitis. With initiation of highly active anti-retroviral treatment (HAART), and without additional antimicrobial or immunosuppressive treatment, he made a major recovery over six weeks to independent...

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  • Intravenous levetiracetam for benzodiazepine refractory status epilepticus
    Susanne Knake

    Dear Editor, Dear Dr. Sethi,

    Thank you very much for sending the eLetter regarding our retrospective case "benzodiazepine refractory status epilepticus". We agree, that standard protocols should be used as the rule as long as levetiracetam is not approved for the treatment of status epilepticus (SE) and as long as there is no prospective randomized study demonstrating the efficacy of levetiracetam in SE. In the pa...

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  • Intravenous levetiracetam for benzodiazepine refractory status epilepticus
    Nitin K Sethi

    Dear Editor

    We read with interest the study by Knake et al. in which they investigated the efficacy and safety of intravenous levetiracetam (ivLEV) for the treatment of status epilepticus 1. Off label usage of LEV is exceedingly common and we would like to commend the authors for providing some data about the efficacy of iv LEV in the treatment of benzodiazepine refractory status epilepticus. All the patients in the...

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  • Gait assessment in central vestibular pseudoneuritis
    James A Nelson

    Dear Editor

    Cnyrim et al have, in "Bedside differentiation of vestibular neuritis from central 'vestibular pseudoneuritis,'" published an important paper that subjects clinical signs of central vertigo to critical analysis (1).
    I do want to state two concerns I have, that I hope will not detract from a sentiment of gratitude and congratulation.

    First, their study population appears t...

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  • Microbleeds and risk of hemorrhagic transformation after ischemic stroke
    Monique M.B. Breteler

    Dear Editor

    We read with interest the paper by Lee et al. on the relation between microbleed presence and risk of hemorrhagic transformation after ischemic stroke (J. Neurol. Neurosurg. Psychiatry Jan 10 2008). Based on data from 377 patients with acute atherothrombotic or cardioembolic stroke, the authors conclude that microbleed presence does not predict hemorrhagic transformation after stroke. Thrombolytic treat...

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  • This may be due to low DHEA.
    James M. Howard

    Dear Editor

    It is my hypothesis that thrombosis/stroke may be due to low DHEA:

    http://www.anthropogeny.com/Thrombosis%20May%20Be%20Caused%20by%20Low%20DHEA.htm

    Many pathological entities associated with thrombosis may be demonstrated to exhibit low DHEA.

    A mother produces DHEA for herself and her fetus. I suggest this split of DHEA may reduce DHEA to very low levels in the mother and tri...

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  • Sporadic Creutzfeldt-Jakob disease may be due to a slow virus infection
    Steven R Brenner

    Dear Editor

    I read the article by Murray concerning sporadic Creutzfeldt-Jakob disease (CJD) in adolescents with interest (1). Seven cases of sporadic CJD in adolescents in all are described (1) without any history of potential iatrogenic exposure.

    Although an infectious protein or prion is considered to be the cause of the transmissible spongiform encephalopaties such as CJD, bovine spongiform encephal...

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  • Is an abrupt “cerebral electrical shutdown” during a seizure the mechanism of SUDEP?
    Mark Stewart

    Dear Editor

    We read with great interest the report by McLean and Wimalaratna [1]. They describe the death during ambulatory EEG monitoring of an adult female epileptic patient. A significant finding was an abruptly “flat line” EEG, and the authors suggested that the cerebral electrical shutdown may have been the cause of death.

    We have been studying the autonomic and cardiovascular consequences of sei...

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  • Incidental findings on MRI and unexpected multiple sclerosis
    Nitin K Sethi
    Dear Editor

    We read with interest the editorial (1) commenting on the paper by Lebrun and colleagues (2). Lebrun and colleagues report a 5 year follow-up of the clinical and MRI findings in patients with subclinical demyelinating lesions fulfilling Barkhof’s criteria on first MRI scan with a normal neurological examination at presentation. None of the 30 patients reported by them had presenting symptoms suggestive of mult...

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