171 e-Letters

published between 2007 and 2010

  • Comment on "Rituximab in patients with chronic inflammatory demyelinating polyradiculoneuropathy: a report of 13 cases and review of the literature"
    Gabriella Zara

    I read with interest the paper by Benedetti et al., entitled 'Rituximab in patients with chronic inflammatory demyelinating polyradiculoneuropathy: a report of 13 cases and review of the literature'(1). Rituximab, a monoclonal antibody that binds to the CD20 antigen on B- lymphocytes, has been approved to eliminate B cell precursors, normal and malignant B cells and to reduce antibody titers (2,3). Some authors argued tha...

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  • extradural cortical stimulation for post-stroke aphasia
    sergio canavero

    Extradural cortical stimulation (ECS) for post-stroke aphasia (PSA)

    Cherney et al (1) conducted an 8 patient controlled study whose conclusion was that ECS may enhance the effect of rehabilitation for PSA. This study was conducted by implanting the stimulating paddle supplied by NorthStar Neuroscience (NSN), a company now out of business. Cherney et al. point to several weaknesses of their study, but omit to dis...

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  • Trial design and current evidence for antibiotics-impregnated ventricular catheters in reducing infections
    George KC Wong

    To the editor,

    We thank Dr. Marini and colleagues for their interest in our article.1 They commented on the use of nosocomial infections as primary outcome and the randomised yet non-double-blinded study design. Secondarily, they shared their disappointing results from the utilization of antibiotics-impregnated ventricular catheters.

    In our centers, we have achieved a ventricular-catheter-related cere...

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  • QoL and Depression
    Paul K Morrish

    Sadjadi and colleagues show that in IBM, as in most chronic illness, mood plays a role in QoL. It would be a surprise if mood didn't play a role in measured QoL. QoL assessment uses subjective measures, for example "how would you rate your health?", and a patient's response to such a question is likely to be altered by mood. Hence QoL questionnaires can also act as mood questionnaires. Indeed, the awkward realisation i...

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  • Awaji Shima criteria for motor neuron disease
    Christopher J McDermott

    Dear Sir, We write in response to the rapid response by Kleine et al. The disparity between the sensitivity of El Escorial in our study (1) and the work by Boekestein et al (2) and de Carvalho (3), we suggest is as a result of the differing neurophysiology protocols. Boekestein et al and de Carvalho use at least 3 times the insertions used in our standard protocols. The protocol used in our study is tailored for everyday...

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    Prahlad Sethi


    PK Sethi*, A Batra**, L Khanna*** Department of Neurology, Sir Gangaram Hospital, New Delhi - 60, India

    While going through the article, The Scan Rule, published in JNNP of March 2010, Vol; 81 explaining the utility of scan score over conventional CT scans in diagnosing or ruling out small intra cerebral haemorrhages, we think that SCAN SCORES cannot score over con...

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  • Prospective analysis of incidence and risk factors of ventricular catheters related CSF infections
    Helene Marini
    Dear Editor, We read with interest the article by Wong et al (J Neurol Neurosurg Psychiatry published online May 12, 2010) suggesting that antibiotic impregnated ventricular catheters are as effective as systemic antibiotics to prevent nosocomial infections and cerebro-spinal fluid (CSF) infections in patients with external ventricular drain.

    Impregnated catheters are designed to prevent specifically CSF catheter related inf...

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  • Half and half
    Andrew G Lee

    An one-and-a-half syndrome as first described by C. Miller- Fisher in 1967 is characterized by an ipsilateral horizontal gaze paresis or palsy and an internuclear ophthalmoplegia or INO on contralateral horizontal gaze. An exotropia may be present in primary position but does not have to be present. The association of exotropia in the one-and-a-half syndrome is sometimes called "paralytic pontine exotropia" In addition t...

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  • Response to "Discrepancy of data?"
    Jerome de Seze

    We thank Dr. Aboul-Enein et al. for their interest about our recent paper. We apologize for the missing references. For the first one (Bichuetti et al.) we missed it in our pubmed research probably due to a misclassification of the key words. For the second one (Aboul-Enein et al.), the paper was not published before our article was in press. We are a little bit concern to include in our references abstract of posters....

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  • "Discrepancy of data?"
    Fahmy Aboul-Enein


    we have read with great interest the paper by de Seze et al., entitled "Magnetic resonance spectroscopy evaluation in patients with neuromyelitis optica" (1).

    Neuromyelitis optica (NMO) is a rare disease and most studies rely on a small sample size. Calling attention to previous publications on magnetic resonance spectroscopy (MRS) in patients with NMO might strengthen the results of de Seze et al. Bi...

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