118 e-Letters

published between 2010 and 2013

  • Poor Man's Immunosuppressant in neuromyelitis optica spectrum disorders: Methotrexate
    Vishnu VY

    Dear Editor: The paper by Joanna Kitley et al1 was consoling at the outset.The understanding about pathogenesis of neuromyelitis optica has greatly increased the use of immunosuppressants for relapse prevention. But in resource limited settings, especially in developing countries most of the patients cannot afford these drugs. Here comes the utility of methotrexate which has been widely used by many neurologists in develo...

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  • Protocol violations and conclusions
    Srijithesh P Rajendran
    Sir, The paper by Rosenow et al1 made interesting reading. However, there are few concerns with respect to the conclusions of the study. The study tested for superiority of levetiratecam over lamotrigine with seizure free interval in the first 6 weeks of the trial as the primary endpoint. Assuming a clinically relevant difference of 15% between the groups, the authors estimated a sample size of 183 patients to achieve power o...
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  • 1p 19q deletion in grade III oligodendroglial tumors and radiological markers.
    Ricardo Prat Ac?n

    We read with interest the work by Kim et al that shows relationship between radiological characteristics and molecular signatures in a group of 49 patients with anaplastic oligodendroglioma (AO) and 7 patients with anaplastic oligoastrocytoma (AOAs). Frontal lobe location, indistinct tumor borders and heterogeneous intratumoral signal intensity were significantly correlated with the 1p19q codeletion. It has been previous...

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  • acute subdural haematoma from intracranial aneurysm rupture
    Fabio Bandini
    Dear editor: We read with interest the paper by Biesbroek et al. "Prognosis of acute subdural haematoma from intracranial aneurysm rupture". We think that, in order to avoid possibile misinterpretations, a clear distinction should be made between acute subdural haematoma (aSDH) associated with subarachnoid haemorrhage (SAH) and aSDH as the sole manifestation of a ruptured intracranial aneurysm, in the absence of SAH. THe latter is...
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    J. Matthijs Biesbroek

    Response to letter regarding article, "The prognosis of acute subdural haematoma from intracranial aneurysm rupture."

    J. Matthijs Biesbroek1, MD; Jan Willem Berkelbach van der Sprenkel1, MD, PhD; Ale Algra1,2, MD; Gabriel J.E. Rinkel1, MD.

    1. Utrecht Stroke Centre, Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, the Netherla...

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    Miguel Gelabert-Gonz?lez

    Dear editor: We read with interest the paper by Biesbroek et al1: "Prognosis of acute subdural haematoma from intracranial aneurysm rupture", and would like to make a number of comments. We are surprised by the author?s treatment protocol in relation to patients with acute subdural hematoma. Why were a large number of patients not subject to arteriography? While a number of clinicians doubt the usefulness of arteriograhp...

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  • Assessing the non motor progression in PD: challenge or chimera?
    Roberto Erro

    Dear Sir, We are pleased with the interest of Weerkamp in our work and are grateful for his comments, giving us the chance to comment the results of our study [1]. We would like to further thank him for having raised the issue of several scales which have been developed to assess the non-motor symptoms (NMS), but include such motor symptoms as morning dystonia and tremor on awakening. However, this is not the case here. I...

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  • Re:Psychogenic non-epileptic seizures: making the right call
    Sean S. O'Sullivan

    We thank the author for his interest in our paper and agree with his comments. In the case of relatively inexperienced clinicians we would caution against over-confidence of PNES diagnosis, and we recommend getting an expert opinion whenever possible. Whilst it has been shown that expert epileptologists seldom all agree (1), perhaps for reasons including "over-thinking" as suggested by Dr. Sethi, epilepsy group meetings ca...

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  • Microscopy versus endoscopy in pituitary surgery
    Juan A Simal-Julian

    We would like to share several observations that we made on Ammirati et al. recently published meta-analysis. The authors reviewed the available English-language literature from 1990 to the present, comparing microsurgery versus endoscopy for treatment of pituitary adenomas, and conducted a systematic review and meta-analysis of the data obtained. The authors concluded that the two treatment methods produced similar out...

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  • Psychogenic non-epileptic seizures: making the right call
    Nitin K. Sethi

    I read with interest O'Sullivan et al. short report on psychogenic non-epileptic seizures (PNES) and how to improve their recognition among physicians not skilled in neurosciences. 1The authors found that diagnostic accuracy and clinical confidence improved after a 15 minute teaching presentation on PNES and epileptic seizures (ES). It is said that the eye cannot see what the mind does not know. One cannot confidently di...

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