eLetters

216 e-Letters

published between 2005 and 2008

  • Migrainous scintillating scotoma and high-grade ICA stenosis: Why the link to CSD is plausible
    Jens P. Dreier

    Dear Editor

    Leão discovered the spreading negative slow voltage variations in response to either direct current electrical stimulation or bilateral occlusion of the internal carotid artery in 1947. Both neurones and astrocytes depolarise during a spreading negative slow voltage variation, thereby inducing transmembraneous ionic shifts and intracellular oedema [1]. Under anoxia or severe ischaemia, this spreading...

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  • Hyperacusis : stapedius dystonia?
    Carmela Gerace

    Dear Editor

    Your paper is very interesting. However we consider hyperacusis symptom a possible disorder of stapedius muscle in your patients: have you evaluated this possibility? Assessement of stapedius function with impedancemetry and measurement of its reflex should be useful in neuromuscular disease including myasthenia gravis and facial nerve paralysis. Actually the stapedius reflex consists of a contractio...

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  • Pathogenesis of ALS
    Heikki Savolainen

    Dear Editor

    The excellent review shows the limits of the descriptive epidemiology in the understanding of the pathogenesis of the amyotrophic lateral sclerosis. The destruction of neurons in its classical form takes place primarily in the motor tracts which would suggest a synaptic neuron to neuron transfer of the harmful factor thus saving initially other networks.

    The hypothetical effect could be relat...

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  • Correction (please print in journal)
    Bart PC van de Warrenburg

    Dear Editor

    In our recent letter entitled “Pisa syndrome after unilateral pallidotomy in Parkinson’s disease: an unrecognised, delayed adverse event?” (J Neurol Neurosurg Psychiatr 2007;78:329-330), we described three Parkinson’s disease (PD) patients who developed a lean to the opposite side several years after a unilateral pallidotomy. We wondered whether this was purely disease-related or perhaps a delayed cons...

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  • Migrainous scintillating scotoma and high-grade ICA stenosis: is the link to CSD plausible?
    Vinod K Gupta

    Dear Editor

    In a patient with high-grade internal carotid artery (ICA) stenosis and frequent migraine aura-like symptoms, Dreier et al [1] demonstrated widely scattered focal laminar cortical infarcts and resolution of visual symptoms following corrective surgery. These authors carry forward the speculation that brain ischemia-related cortical spreading depression (CSD) underlies the associated visual phenomena....

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  • The Speculated Mechanism of BBB disruption in TBI
    Kao-Chang Lin

    Dear Editor

    This is an interesting issue about post-traumatic epilepsy (PTE) in brain injured (TBI) patients (1). The authors use spectral electroencephalography (EEG), and brain Magnetic Resonance Image study (bMRI) with contrast (Gadolinium -DTPA) using semi-quantitative technique to define the abnormal signals, and found that MRI but not EEG is more useful to reveal the abnormal cortical signals and can predi...

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  • Vision Restoration Therapy: a reply
    Lies Bouwmeester

    Dear Editor,

    We write in response to the eLetter by Philip L Clatworthy on our systematic review ‘the effect of visual training for patients with visual field defects due to brain damage’ (1).

    The focus of the study was to contribute to the development of appropriate methods for patients with visual field defects. During the literature search we were amazed that there were only few methodological sound tr...

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  • Ethics in deep brain stimulation for alcohol dependence
    Emily C Bell

    Dear Editor

    JJ Kuhn and colleagues (2007) report a remarkable change in abuse and dependence behavior using DBS neurosurgery.(1)

    First, before DBS could become a potential therapeutic option in alcohol dependence, several factors should likely be considered as suggested by the authors. A key consideration in extending DBS to alcohol dependent patients would be the fact that many patients seeking treatmen...

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  • chorea induced by pontine lesions.
    Harald De Cauwer

    Dear Editor

    We read with interest ‘Hydrocephalus induced chorea’ by Voermans, Schutte, and Bloem (J Neurol Neurosurg Psychiatry 2007; 78: 1284-1285). They discuss the causal relation between white matter lesions in the basal ganglia and chorea. Pontine lesions however are not mentioned. We found in this journal two previous cases of pontine myelinolysis and extrapontine myelinolysis and extrapiramidal symptoms.1...

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  • Retrograde cerebral venous air embolism, a grossly underestimated differential diagnosis.
    Christoph J. Schlimp

    Dear Editor

    We read with great interest the submitted neurological picture of Jeon et Kang.(1) Together with two recent case reports in the neuroscience field,(2,3) it might have failed to spot the grossly underestimated differential diagnosis of retrograde cerebral venous air embolism secondary to central venous access.(4) In contrast to the well studied and reported paradoxical cerebral arterial air embolism in...

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