171 e-Letters

published between 2007 and 2010

  • Endogenous morphine production may be impaired in both migraine and restless legs syndrome
    Steven R. Brenner

    I read the article on association of restless legs and migraine headache by Chen with interest (1).

    Probably the two conditions share basic neuronal abnormalities such as neurotransmitter dysfunction.

    Opiates are an effective treatment for restless legs and also for the pain of migraine headaches.

    Morphine has been found to be produced endogenously in the nervous system (2) and is also a neu...

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  • A fundamental bias of the research: Overlooking Congenital Acidosic Enzyme-Metabolic Histangiopaty-Dependent Brain Inherited Real Risk.
    Sergio Stagnaro

    Editors, there is a fundamental bias in this study. In fact, because congenital functional mitochondrial cytopathology is overlooked, which is the "conditio sine qua non" of numerous constitutions and thus of the most frequent and dangerous human disorders, including malignancies, all current researches are fundamentally biased . That is, authors do not consider the existence or assess the seriousness as well as the l...

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  • Awaji criteria: too complex?
    Bert U. Kleine

    Dear Editor,

    With great interest we read the retrospective application of the Awaji criteria (1) by Douglas et al. (2). In this paper the authors validated the Awaji criteria in a routine clinical setting. A remarkable finding is that after EMG assessment only one patient could be classified as probable laboratory supported ALS. Consequently a low sensitivity of the revised El Escorial criteria was found. This...

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  • It is One and Half syndrome, not Half and Half syndrome
    Farrukh Akram Baig
    I wish to draw your attention to the effect that the title is erroneous. The condition discussed is ONE AND HALF syndrome and not HALF AND HALF syndrome as proposed by the authors. There is no information in the published literature of existence of a condition called Half and Half syndrome. We are currently in process of submitting an interesting case of ONE and HALF SYNDROME and its response to intavenous immunoglobulins at our S...
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  • Rituximab for Myasthenic Crisis
    Marcelo D. Schafranski

    It was with great interest that we read the article published in the Journal where rituximab was successfully used to treat myasthenia gravis refractory cases (1). Here, we describe a case where the drug was administered in a difficult-to treat-myasthenic crisis. A 65-year-old woman who suffered from myasthenia gravis since 2006 was admitted to the intensive care unit (ICU) in severe respiratory distress. The patient was...

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    Novel descriptions of methodologies , tools and diagnostic devices have emeerged in the context of diagnosis / treatment of Freezing of gait ( FOG ) in parkinson 's disease. defined as a sudeen and unpredictable mechanism with the patient ' glued ' to the floor or altered step frorward , which onset may be conditioned by turning , step initiation , esternal stimuli or spatial constratint . A plenty of observation tools h...

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  • Superoxide dismutase in brain
    Heikki Savolainen

    Dear Editor,

    I have read with the greatest interest the large investigation on the mutated superoxide dismutase (SOD) frequency in the Dutch amyotrophic lateral sclerosis patients (1). The results seem to show that is very rare in the Netherlands, or it may be only an epiphenomenon from the point of view of the disease pathogenesis.

    This conclusion could be reconciled with the circumstance that a large...

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    Sabino G. Echebarria

    Vestibular paroxysmia has been defined classically by series of rotational to-and-fro vertigo, precipitated or modulated by head position.Then , descriptional basis of the clinical picture may be disclosed if vertigo may be associated to hipoacusis and tinitus or not.

    In the case of pure tinnitus description , the loud / low pitch sound of the tinnitus may be defined as paroxysmal tinnitus. Ethilogical purposes...

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  • Comment on "Magnetic resonance spectroscopy evaluation in patients with neuromyelitis optica"
    Denis B. Bichuetti

    Dear Editor,

    We read with interest the article written by de Seze et al(de Seze, Blanc et al. 2010), published on the April 2010 issue of the Journal of Neurology, Neurosurgery and Psychiatry. The authors describe a transversal investigational research comparing magnetic resonance spectroscopy (MRS) of NAWM and NAGM of 24 patients with NMO, 46% of whom had brain abnormalities, and 12 healthy subjects. In this st...

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  • Re:Transcranial magnetic stimulation is a useful diagnostic test in psychogenic paralysis
    Ruth Geraldes

    I thank Dr. Civardi and his group, who have demonstrated a large experience with the practical use of Motor Evoked Potentials, for their interest in our article describing a patient with presumed psychogenic left hemiparalysis and abnormal transcranial magnetic stimulation (TMS) (1). Our initial aim in performing TMS to our patient was exactly to prove that MEPs were normal, as suggested by other authors (including Dr. C...

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