129 e-Letters

published between 2009 and 2012

  • Early therapeutic intervention for hyponatremia after subarachnoid haemorrhage
    Satoru Takeuchi

    We read with interest the recent study by Zheng et al.[1] The authors assessed the predictive value of hyponatremia for poor outcome or cerebral infarction in high-grade patients after aneurysmal subarachnoid haemorrhage (aSAH), and concluded that hyponatremia did not predict poor outcome in all-grade aSAH patients, whereas late-onset (3 days after aSAH) hyponatremia in high-grade aSAH patients was associated with cerebral...

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  • Response to the comments of Dr Aboul-Enein on the article 'Frequency of cognitive impairment dramatically increases during the first five years of multiple sclerosis' by Reuter et al.
    Francoise Reuter
    We thank Dr Aboul-Enein for asking us to discuss in more details some results of the study published recently by Reuter et al that provides the prevalence of cognitive impairment in patients with early multiple sclerosis explored after a clinical isolated syndrome and 5 years later. This study demonstrates that the proportion of patients suffering from cognitive impairment almost doubles between baseline (29%) and five years (54%)...
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  • RE: The natural history of epilepsy: an epidemiological view
    Seye Abimbola

    Dear editor,

    The synthesis of epidemiological studies of the natural history of treated and untreated epilepsy proposed in 2004 by Kwan and Sander(1) separates people with epilepsy into 3 prognostic groups. However, further interpretation of available evidence suggest that this prognostic groups could be further subdivided:

    Group 1 is the group of patients who would enter remission with or without an...

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  • Comment on the article entitled 'Frequency of cognitive impairment dramatically increases during the first 5 years of multiple sclerosis' by Reuter F, Zaaraoui W, Crespy L, Faivre A, Rico A, Malikova I, Soulier E, Viout P, Ranjeva JP, Pelletier J, Audo
    Fahmy Aboul-Enein

    Dear Sir, We have read with great interest the article by Reuter et al. entitled 'Frequency of cognitive impairment dramatically increases during the first 5 years of multiple sclerosis' 1 , which seems related to another recent published article. 1,2

    Whether steadily ongoing, but clinically silent axonal changes occur in all MS patients and MS subtypes, and if so, progressive axonal changes occur already at...

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  • Re:Aortic arch and ulcerative plaques
    Kanzunori Toyoda

    We appreciate the comment regarding our study on ulcerated plaque in the aortic arch.

    As the commenter pointed, vascular neurologists might have believed that the aortic plaque configuration was as important as the plaque thickness when aortogenic embolism was assessed. Our study could identify a strong association between ulcerated plaque and recent multiple brain infarction, which was possibly caused by rec...

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  • Smoking and Exercise in Combination may adversely affect mitochondrial function and cause ALS in susceptible individuals
    Steven R Brenner

    I read the article by Alonso on smoking and risk of amyotrophic lateral sclerosis (ALS) with interest (1) While the meta-analysis may not support a strong association with smoking and ALS, there may be a relationship with the combination of smoking and exercise. Smoking increases carbon monoxide (CO) levels (2) and cyanide (3) in the blood. Cyanide binds with cytochrome oxidase in the mitochondria, and CO interferes wi...

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  • Non-paraneoplastic limbic encephalitis associated with amphiphysin antibody in Taiwanese children
    Huei-Shyong Wang

    We read with great interest the article about non-paraneoplastic limbic encephalitis (LE) associated with NMDAR and VGKC antibodies by Pellkofer et al (1).

    In the analysis of National Hospital Discharge data, the cause of encephalitis was unknown in 60% of cases (2). We have similar experience in children. Recently, we found about one third of those unknown childhood non-paraneoplastic encephalitides had positi...

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  • The cutoff point of spinocerebellar ataxia type 17 should be lowered to 42 trinucleotide repeats
    Jong-Min Kim

    We read with great interest the article by Nolte et al. on the spinocerebellar ataxia type 17 (SCA17) associated with a trinucleotide repeats (TNR) number of 42.[1] The authors examined 285 patients with ataxia, and found eight cases of SCA17. Of those, four patients had 42 TNR, which is one codon less than the generally accepted threshold of 43. They contended that the definition of TNR for pathological SCA17 should be...

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  • Re:Possibility of epigenetic events in the pathogenesis of ALS
    Ammar Al-Chalabi

    Dear Editor,

    We agree that genetic studies have so far explained only a small fraction of the heritability of ALS (1,2), and this is true in many other diseases as well (3). Epigenetic factors are almost certainly part of the answer, but there are also several other possibilities. We are only just developing the tools to look for disease-associated rare variants on a large scale. In addition, we do not understa...

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  • Possibility of epigenetic events in the pathogenesis of ALS
    Heikki Savolainen

    Dear Editor,

    The twin studies show conclusively the limits of classical genetics in the studies of the etiology and pathogenesis of the ALS (1).

    It has been suggested that a susceptibility or familial factor could play a role. In this case, they may be mediated by epigenetic mechanisms which control the activity and expression of the genome (2).

    The incorrectly coded polypeptides could lead to...

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