eLetters

190 e-Letters

published between 2006 and 2009

  • Medications for attention deficits in traumatic brain injury: When is the ideal time?
    Manoj Sivan

    Dear Editor,

    I congratulate Catherine Willmott and Jennie Ponsford for their excellent study on use of methylphenidate for attention rehabilitation in an inpatient setting [1]. As they claim, their study is indeed the largest controlled trial on use of methylphenidate for attention deficits in traumatic brain injury.

    It is interesting to see that patients in their study with greater injury severity s...

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  • Longitudinal multimodal imaging in mild to moderate Alzheimer disease: a pilot study with memantine
    Cindy B. Kim

    Dear Editor,

    The two objectives of the study conducted by Schmidt et al.(1) were to test: A) the feasibility of multimodal imaging in Alzheimer’s disease (AD); and B) the effects of memantine in AD. We were unclear as to why the two objectives were not studied separately. Testing the feasibility of multimodal imaging procedures may be clinically valuable. However, we did not understand why it was necessary t...

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  • The effects of memantine treatment on Alzheimer disease for a year are uncertain
    Steven R Brenner

    Dear Editor,

    I read the article by Schmidt (1) with interest with respect to the effects of memantine on multimodal imaging in Alzheimer’s disease.

    The results of the study indicated some possible beneficial effects of memantine treatment after a year, however the volumetric studies did not reach statistical significance which would indicate effects of treatment were uncertain with respect to imaging...

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  • “Upper facial nerve motor evoked potentials” can be a misinterpretation of the blink reflex
    Isabel Fernandez-Conejero

    Dear Editor,

    We read with great interest the article by Fukuda et al. “Facial nerve motor-evoked potential monitoring during skull base surgery predicts facial nerve outcome.” (J Neurol Neurosurg Psychiatry 2008; 79:1066-1070).

    In this rather small group of 26 patients with skull base tumors, the authors have tried to establish a role for facial nerve motor evoked potentials (FNMEPs) to predicting the neuro...

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  • Chronic cerebrospinal venous insufficiency: a potential weakening factor of the blood-brain barrier
    Marian Simka

    Dear Editor,

    Multiple sclerosis is believed to be an autoimmune pathology, yet the mechanisms triggering the disease remain elusive. Therefore, I read with great interest the paper by Zamboni and his team who investigated the venous hemodynamics in patients with multiple sclerosis. His findings that this disease might be attributable to venous refluxes shed new light on the facts that have been known for decades...

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  • Methodological flaws in meta-analysis may lead to misleading conclusions
    Sophie L. Rogers

    Dear Editor,

    We are writing in response to the meta-analysis by Doubal, Hokke and Wardlaw “Retinal Microvascular Abnormalities and Stroke – A Systematic Review” published online on 17 October 2008. While the paper is well written, the topic interesting and potentially important, we have several concerns regarding the methodological rigor of the meta-analysis.

    The fundamental issue is inappropriate poo...

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  • Dementia in parkinson disease: need of clarification
    Gurutz Linazasoro

    Dear Editor,

    I have read with great interest the article by Edison et al about the amyloid load in patients with Parkinson´s disease (PD), PD with dementia (PDD) and dementia with Lewy bodies (DLB) (1). Authors hypothesised that amyloid pathology would be uncommon in PD without dementia, an occasional feature of PDD and present in the majority of DLB cases. This hypothesis was clearly demonstrated (1). However,...

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  • Kernohan Notch, Retractor Crunch, or Interhemispheric Diaschisis:
    Iraj Derakhshan

    Dear Editor,

    I read the article of Yoo et al [1] in the Journal with interest and would like to offer another explanation as to the cause of delayed and weaker response of the right ABP to transcranial magnetic stimulation of the right hemisphere, i.e. interhemispheric diaschisis.

    Firstly, there is substantial number of case reports documenting ipsilateral paralysis in unilateral cranial lesions (e.g....

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  • Various observations on this study
    Tom P Kindlon

    Dear Editor,

    The authors report that "those taking antidepressants had a higher median (interquartile range) body mass ratio (25.0 (21.4-27.6) versus 22.0 (20.0-25.2) (p=0.03) and a shorter median (interquartile range) time on the treadmill (8.6 (6-11) versus 11.0 (8-12) minutes) (p=0.02). They also had a significantly lower mean (SD) peak VO2 (27.9 (9.0) versus 32.8 (7.0) ml/kg/min) (p=0.02)." In the discussion...

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  • STN-DBS in genetic Parkinson's disease patients
    Simon Israeli-Korn

    Dear Editor,

    We have read with interest the article by Soulas and colleagues entitled "Attempted and completed suicides after subthalamic nucleus stimulation for Parkinson's disease". (1)The authors reported a committed suicide rate of at least 1% and a 2% attempted suicide rate in a retrospective cohort of Parkinson's disease (PD) patients who underwent bilateral subthalamic deep brain stimulation (STN DBS). T...

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