154 e-Letters

published between 2008 and 2011

  • QoL and Depression
    Paul K Morrish

    Sadjadi and colleagues show that in IBM, as in most chronic illness, mood plays a role in QoL. It would be a surprise if mood didn't play a role in measured QoL. QoL assessment uses subjective measures, for example "how would you rate your health?", and a patient's response to such a question is likely to be altered by mood. Hence QoL questionnaires can also act as mood questionnaires. Indeed, the awkward realisation i...

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  • Awaji Shima criteria for motor neuron disease
    Christopher J McDermott

    Dear Sir, We write in response to the rapid response by Kleine et al. The disparity between the sensitivity of El Escorial in our study (1) and the work by Boekestein et al (2) and de Carvalho (3), we suggest is as a result of the differing neurophysiology protocols. Boekestein et al and de Carvalho use at least 3 times the insertions used in our standard protocols. The protocol used in our study is tailored for everyday...

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    Prahlad Sethi


    PK Sethi*, A Batra**, L Khanna*** Department of Neurology, Sir Gangaram Hospital, New Delhi - 60, India

    While going through the article, The Scan Rule, published in JNNP of March 2010, Vol; 81 explaining the utility of scan score over conventional CT scans in diagnosing or ruling out small intra cerebral haemorrhages, we think that SCAN SCORES cannot score over con...

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  • Prospective analysis of incidence and risk factors of ventricular catheters related CSF infections
    Helene Marini
    Dear Editor, We read with interest the article by Wong et al (J Neurol Neurosurg Psychiatry published online May 12, 2010) suggesting that antibiotic impregnated ventricular catheters are as effective as systemic antibiotics to prevent nosocomial infections and cerebro-spinal fluid (CSF) infections in patients with external ventricular drain.

    Impregnated catheters are designed to prevent specifically CSF catheter related inf...

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  • Half and half
    Andrew G Lee

    An one-and-a-half syndrome as first described by C. Miller- Fisher in 1967 is characterized by an ipsilateral horizontal gaze paresis or palsy and an internuclear ophthalmoplegia or INO on contralateral horizontal gaze. An exotropia may be present in primary position but does not have to be present. The association of exotropia in the one-and-a-half syndrome is sometimes called "paralytic pontine exotropia" In addition t...

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  • Response to "Discrepancy of data?"
    Jerome de Seze

    We thank Dr. Aboul-Enein et al. for their interest about our recent paper. We apologize for the missing references. For the first one (Bichuetti et al.) we missed it in our pubmed research probably due to a misclassification of the key words. For the second one (Aboul-Enein et al.), the paper was not published before our article was in press. We are a little bit concern to include in our references abstract of posters....

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  • "Discrepancy of data?"
    Fahmy Aboul-Enein


    we have read with great interest the paper by de Seze et al., entitled "Magnetic resonance spectroscopy evaluation in patients with neuromyelitis optica" (1).

    Neuromyelitis optica (NMO) is a rare disease and most studies rely on a small sample size. Calling attention to previous publications on magnetic resonance spectroscopy (MRS) in patients with NMO might strengthen the results of de Seze et al. Bi...

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  • Endogenous morphine production may be impaired in both migraine and restless legs syndrome
    Steven R. Brenner

    I read the article on association of restless legs and migraine headache by Chen with interest (1).

    Probably the two conditions share basic neuronal abnormalities such as neurotransmitter dysfunction.

    Opiates are an effective treatment for restless legs and also for the pain of migraine headaches.

    Morphine has been found to be produced endogenously in the nervous system (2) and is also a neu...

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  • A fundamental bias of the research: Overlooking Congenital Acidosic Enzyme-Metabolic Histangiopaty-Dependent Brain Inherited Real Risk.
    Sergio Stagnaro

    Editors, there is a fundamental bias in this study. In fact, because congenital functional mitochondrial cytopathology is overlooked, which is the "conditio sine qua non" of numerous constitutions and thus of the most frequent and dangerous human disorders, including malignancies, all current researches are fundamentally biased . That is, authors do not consider the existence or assess the seriousness as well as the l...

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  • Awaji criteria: too complex?
    Bert U. Kleine

    Dear Editor,

    With great interest we read the retrospective application of the Awaji criteria (1) by Douglas et al. (2). In this paper the authors validated the Awaji criteria in a routine clinical setting. A remarkable finding is that after EMG assessment only one patient could be classified as probable laboratory supported ALS. Consequently a low sensitivity of the revised El Escorial criteria was found. This...

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