eLetters

616 e-Letters

  • Case report does not report sufficient data to support a diagnosis of fatal organophosphorus poisoni
    Michael Eddleston

    Dear Editor,

    We note the report of an unusual organophosphorus (OP) pesticide poisoning published in your journal [1]. However, from the data presented, we are not convinced that the patient’s death can be attributed to OP poisoning. Furthermore, we do not believe that this report can be used to expand the spectrum of syndromes seen following OP poisoning.

    There was no history of ingestion of an OP. In a...

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  • Neurobiology of "Stops walking when talking"
    Ernest H. Friedman

    Dear Editor,

    Hyndman and Ashburn [1] find that those who stopped walking when talking were significantly more disabled (p...

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  • Re: Clinical use of paraneoplastic antibodies
    Jeremy H Rees

    Dear Editor

    Dr Grueger raises an interesting and relevant management point about the usefulness or not of testing patients with suspected paraneoplastic neurological disease for the presence of anti-neuronal antibodies.

    I do not agree however that this test has no benefit. These antibodies are highly specific for an underlying tumour e.g. anti-Hu for small cell lung cancer and anti-Yo for breast and gy...

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  • Platelet-leukocyte adhesion, migraine, and stroke: a bioclinical perspective
    Vinod K Gupta

    Dear Editor

    Zeller et al showed platelet adhesion to leukocytes during the headache-free interval and a higher baseline of platelet activation in migraine patients without aura; the authors suggest a link between migraine and stroke at the cellular level [1]. Also, they believe that enhanced platelet activation in migraine patients is a marker of the inflammatory process in the trigeminovascular system.

    ...
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  • Response to Letter to the Editor Wenneberg R.
    W. Brent Tarver

    Dear Editor

    In the Letter to the Editor (Wennberg R. Short term benefit of battery depletion in vagus nerve stimulation for epilepsy. J Neurol Neurosurg Psychiatry 2004;75:939), the author stated that 58% of subjects improved after battery depletion.

    The information provided in the VNS Therapy Physician's Manual states that the information provided was referenced to BASELINE, not to the time just befor...

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  • To sleep or not to sleep
    Mark RA Manford

    Dear Editor

    The authors [1]. usefully describe a large series of patients and compare the occurrence of non-epileptic seizures arising whilst apparently asleep.

    This clinical differentiation remains problematic and the rule appears to be emerging that there are no rules. However, to my knowledge there is only one study [2]. (quoted by Duncan et al) with video-EEG-recording, maintaining that patients can...

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  • Botulinum toxin for treatment of migraine: randomized controlled trials versus basic sciences
    Vinod K Gupta, M.D.

    Dear Editor

    Jankovic reviews the expanding list of approved and off-label indications for therapeutic use of botulinum toxin (BT). [1]. One of the prominent off-label indications for use of BT is migraine, the advent of which therapy was serendipitous.

    Use of BT for migraine prevention is gaining momentum through the results of randomized controlled trials (RCT) – both completed and ongoing – and, in th...

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  • Impaired swallowing reflex in dysphagic stroke patients - a reply to Teramoto et al.
    Rainer Dziewas

    Dear Editor

    We appreciate the interesting comment on our paper [1] and the important clinical observations by Teramoto et al.

    In their recent studies the authors have shown that the simple swallowing provocation test (SPT) is able to identify patients being predisposed to aspiration pneumonia.[2,3] Based on their experience, featuring a failure of the SPT in 18 of 26 patients (70%), the authors are rig...

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  • Triphasic effects of organophosphate poisoning, Is it an over simplification?
    Tissa Wijeratne

    Dear Editor

    We read with interest the letter by Teke et al,[1] which described a case of organophosphate (OP) poisoning with atypical features and also the magnetic resonance imaging (MRI) findings. The number of acute pesticide poisoning is estimated at three million a year world wide, resulting in over 200,000 deaths.[2,3] In a survey of deaths due to acute poisoning in the District of Kandy , Sri Lanka f...

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  • Clinical use of paraneoplastic antibodies
    Albert Grueger

    Dear Editor

    How useful is antibody testing for paraneoplastic disease in a patient without known tumour?

    Dr Rees proposes to search for paraneuroplastic antibodies in patients with possible paraneoplastic syndromes. At the same time he points out that the incidence of specific disabling neurological paraneoplastic syndromes is very low. No information on the sensitivity and specifity of an antibody scre...

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