154 e-Letters

published between 2008 and 2011

  • Metabolic syndrome and the dementias: a link between Alzheimer disease and vascular dementia?
    Sotirios Giannopoulos

    Metabolic syndrome and the dementias: a link between Alzheimer disease and vascular dementia?

    Sotirios Giannopoulos, Athanassios P. Kyritsis, Maria Kosmidou, Haralampos J. Milionis

    Departments of Neurology & Internal Medicine University of Ioannina School of Medicine, Ioannina, Greece

    Key words: metabolic syndrome; Alzheimer disease; vascular dementia; cerebrovascular disease;


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  • Chronic ataxic neuropathy associated with antibodies to disialogangliosides responsive to Rituximab.
    Chiara Briani

    Dear Editor, we read with great interest the paper by Attarian et al on response to Intravenous immunoglobulin (IVIg) therapy in patients with chronic ataxic neuropathies and anti-GD1b antibodies. We would like to share our experience with a patient with chronic ataxic demyelinating polyneuropathy and antibodies to disialogangliosides who responded to Rituximab therapy. A 69-year-old man presented in August 2006 with sub...

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  • Transcranial magnetic stimulation is a useful diagnostic test in psychogenic paralysis
    Carlo Civardi

    Dear Editor,

    I read with interest the article by Geraldes et al.[1] on the use of transcranial magnetic stimulation (TMS) in psychogenic paralysis. The Authors showed in a young lady with a reversible left body limbs paresis due to conversion disorders (CD), a significant increase of corticomotor threshold and reduction in amplitude of motor evoked potentials (MEP) in the affected side. These changes were resto...

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  • Autosomal dominant axonal Charcot-Marie-Tooth disease associated with dynamin 2 gene mutations
    José Berciano

    I read with interest the excellent review on Charcot-Marie-Tooth disease (CMT) by Reilly and Shy (1). I wish to make a brief comment on CMT associated with dynamin 2 gene mutations. This CMT subtype is currently classified within dominant intermediate CMT type B (DI-CMTB), as electrophysiological study characteristically shows motor conduction velocities in the intermediate range (25-45 m/s). There are, however, three re...

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  • Stroke in Fabry disease frequently occurs in the absence of prior multisystem involvement
    Thierry Zenone

    To the editor: I read with interest the case report recently published in your journal. In this paper, Gregoire and colleagues describe a 24-year-old man with strokes without systemic involvement as the presenting feature of Fabry disease. They conclude that a pure cerebrovascular presentation of Fabry disease without prior multisystem involvement (mainly, cardiomyopathy, skin lesions or renal involvement) has not previo...

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  • Diffusion restriction in an early phase of Wallerian degeneration along the corticospinal tract.
    Toshio Moritani

    This is a typical case of diffusion restriction in an early phase of Wallerian degeneration along the left corticospinal tract secondary to a large left putaminal hemorrhage. Diffusion weighted (DW) imaging shows the early phase of wallerian degeneration as hyperintense associated with decreased ADC, presumably representing axonal and reactive astrocytic swelling [1, 2]. DW high signals can be observed after more than 24...

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  • Predicting the risk of aneurysm rupture is something different than identifying risk factors.
    Jacoba P. Greving

    Dear Editor,

    With interest we read the article by You et al. describing the identification of risk factors for aneurysm rupture and providing estimations for the likelihood of rupture in unruptured intracranial aneurysms [1]. However, we have concerns about the study design, the presented analysis and the conclusions regarding the predictors for aneurysm rupture.

    First, the authors used a study popul...

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  • Weight gain following subthalamic deep brain stimulation in Parkinson's disease
    Harrison C. Walker

    Dear Editor,

    We read with interest the manuscript by Bannier et al[1] describing weight gain at 16 months following bilateral subthalamic nucleus deep brain stimulation (STN DBS) placement in patients with Parkinson's disease (PD). The authors concluded that weight gain following DBS is “life- threatening,” increases cardiovascular risk, and is more than a mere normalization towards a baseline weight in the absenc...

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  • Brainstem involvement in neuromyelitis optica
    Kai Chen Wang

    Dear Editor,

    I read with interest the article by Viegas et al. 1 about the symptomatic, radiological and pathological involvement of the hypothalamus in neuromyelitis optica (NMO). Their case review of a young lady presented with spontaneous vomiting and behavioral change, confirmed the diagnosis of NMO after the identification of aquaporin 4 antibody(AQP4 Ab).

    We also have many patients presented with...

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  • The role of cerebrospinal fluid glial fibrillar acidic protein levels in neuromyelitis optica
    Roberta M S Costa

    Dear Editor,

    In the article “Marked increase in cerebrospinal fluid glial fibrillar acidic protein in neuromyelitis optica: an astrocytic damage marker” J. Neurol. Neurosurg. Psychiatry 2009;80;575-577, the authors found a significant increase in the CSF-GFAP levels during relapse in NMO patients which were several thousand times higher than those found in other neurological diseases (MS, OND, spinal infarct...

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