RT Journal Article
SR Electronic
T1 Hypothalamic lesions in multiple sclerosis
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 819
OP 822
DO 10.1136/jnnp.2009.198192
VO 82
IS 7
A1 Qiu, Wei
A1 Raven, Sonja
A1 Wu, Jing-Shan
A1 Bundell, Christine
A1 Hollingsworth, Peter
A1 Carroll, William M
A1 Mastaglia, Frank L
A1 Kermode, Allan G
YR 2011
UL http://jnnp.bmj.com/content/82/7/819.abstract
AB Objectives To determine the frequency of hypothalamic lesions in patients with multiple sclerosis (MS) using conventional MRI (cMRI) protocols.Methods Brain cMRI (1.5 Tesla) scans of 105 Caucasian patients with classical MS (50 with stable and 55 with more active disease) and 12 patients with longitudinal extensive myelopathy (LEM) were reviewed retrospectively. NMO-IgG antibody was assayed in patients with hypothalamic lesions.Results Hypothalamic lesions were found in 13.3% of MS patients and in none of the LEM patients. A higher frequency of hypothalamic lesions was found in patients with active MS (18.2%) than in the stable group (8.0%), but this did not reach statistical significance (p=0.13). Patients with hypothalamic lesions also had more lesions in other cerebral structures. None of the LEM patients had hypothalamic lesions. No patients with hypothalamic lesions were positive for NMO-IgG.Conclusions Hypothalamic lesions in MS are more frequent than previously reported and are not associated with NMO-IgG antibody.