TY - JOUR T1 - The central nervous system in motor neurone disease JF - Journal of Neurology, Neurosurgery & Psychiatry JO - J Neurol Neurosurg Psychiatry SP - 338 LP - 357 DO - 10.1136/jnnp.33.3.338 VL - 33 IS - 3 AU - Betty Brownell AU - D. R. Oppenheimer AU - J. Trevor Hughes Y1 - 1970/06/01 UR - http://jnnp.bmj.com/content/33/3/338.abstract N2 - Forty-five necropsied cases with primary degeneration of lower motor neurones are described and discussed. Of these, 36 are considered to be `typical' cases of motor neurone disease, eight of which showed no upper motor neurone lesions. The relation of the nine `atypical' cases to the remainder is discussed. It is concluded that motor neurone disease constitutes an ill-defined band in a broad spectrum of multiple system atrophies. The authors have found no evidence suggesting a causal relation between motor neurone disease and either vascular or malignant diseases. They point out suggestive analogies with various subacute encephalomyelopathies in man and other animals. ER -