TY - JOUR T1 - Use of cerebrospinal fluid drawn at pneumoencephalography in the study of monoamine metabolism in man JF - Journal of Neurology, Neurosurgery & Psychiatry JO - J Neurol Neurosurg Psychiatry SP - 704 LP - 710 DO - 10.1136/jnnp.37.6.704 VL - 37 IS - 6 AU - E. Garelis AU - T. L. Sourkes Y1 - 1974/06/01 UR - http://jnnp.bmj.com/content/37/6/704.abstract N2 - Concentrations of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) were significantly higher in CSF obtained after injection of air during pneumoencephalography (PEG) than in lumbar CSF, as drawn before the injection. There was a high correlation between levels in the `mixed' and lumbar samples of CSF in the case of each of the two acids. The concentration of lumbar HVA, but not that of 5-HIAA, was negatively correlated with CSF pressure. 5-HIAA levels were low in both samples of CSF in a group of epileptics, by comparison with controls. In two patients with Kufs disease and in one with Niemann-Pick disease, the concentration of HVA was very low in the lumbar sample. The application of a standardized PEG technique in the study of monoamine metabolism in man is suggested. ER -