RT Journal Article
SR Electronic
T1 Use of cerebrospinal fluid drawn at pneumoencephalography in the study of monoamine metabolism in man
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 704
OP 710
DO 10.1136/jnnp.37.6.704
VO 37
IS 6
A1 E. Garelis
A1 T. L. Sourkes
YR 1974
UL http://jnnp.bmj.com/content/37/6/704.abstract
AB Concentrations of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) were significantly higher in CSF obtained after injection of air during pneumoencephalography (PEG) than in lumbar CSF, as drawn before the injection. There was a high correlation between levels in the `mixed' and lumbar samples of CSF in the case of each of the two acids. The concentration of lumbar HVA, but not that of 5-HIAA, was negatively correlated with CSF pressure. 5-HIAA levels were low in both samples of CSF in a group of epileptics, by comparison with controls. In two patients with Kufs disease and in one with Niemann-Pick disease, the concentration of HVA was very low in the lumbar sample. The application of a standardized PEG technique in the study of monoamine metabolism in man is suggested.