RT Journal Article SR Electronic T1 Comparative trial of benzhexol, amantadine, and levodopa in the treatment of Parkinson's disease JF Journal of Neurology, Neurosurgery & Psychiatry JO J Neurol Neurosurg Psychiatry FD BMJ Publishing Group Ltd SP 422 OP 426 DO 10.1136/jnnp.37.4.422 VO 37 IS 4 A1 J. D. Parkes A1 R. C. Baxter A1 C. D. Marsden A1 J. E. Rees YR 1974 UL http://jnnp.bmj.com/content/37/4/422.abstract AB Fourteen slightly disabled patients with Parkinsonism were treated separately with benzhexol, amantadine, and levodopa. Benzhexol and amantadine both gave a 15% reduction in functional disability and levodopa a 36% reduction. Benzhexol lessened the rigidity and improved the flexion of posture of Parkinson's disease, but had little or no effect on akinesia and tremor. Amantadine and levodopa caused improvement in all these symptoms. The combination of benzhexol and amantadine was as effective after four weeks of treatment as levodopa was after six months.