RT Journal Article
SR Electronic
T1 Motor neurone disease: the nature of the pathogenic mechanism
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 1036
OP 1046
DO 10.1136/jnnp.37.9.1036
VO 37
IS 9
A1 Mann, D. M. A.
A1 Yates, P. O.
YR 1974
UL http://jnnp.bmj.com/content/37/9/1036.abstract
AB Evidence is presented which indicates that the initial site of action of the pathogen of motor neurone disease (MND) is the nucleus, and its prime effect is to cause the progressive inhibition of DNA directed mRNA synthesis by the slow condensation of chromatin from a metabolically active diffuse form to an inactive form. The other pathological changes observed follow as part of a nonspecific cell atrophy which leads eventually to dysfunction, death, and disappearance of cells.