RT Journal Article
SR Electronic
T1 Anticholinergic withdrawal and benzhexol treatment in Parkinson's disease
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 936
OP 941
DO 10.1136/jnnp.36.6.936
VO 36
IS 6
A1 P. M. Horrocks
A1 D. J. Vicary
A1 J. E. Rees
A1 J. D. Parkes
A1 C. D. Marsden
YR 1973
UL http://jnnp.bmj.com/content/36/6/936.abstract
AB The effects of slow withdrawal of anticholinergic medication and addition of benzhexol (8 mg/day) have been studied in patients with Parkinson's disease on stable levodopa therapy. Withdrawal of anticholinergic drugs led to measurable and often severe deterioration in about two-thirds of patients. Addition of benzhexol produced a slight but definite additional improvement in those patients in whom anticholinergics were withdrawn before the trial. Anticholinergic drugs thus still have a part to play in the treatment of Parkinson's disease, for they produce benefit in addition to that provided by levodopa.