PT  - JOURNAL ARTICLE
AU  - F B Gibberd
AU  - M Webley
TI  - Studies in man of phenytoin absorption and its implications.
AID  - 10.1136/jnnp.38.3.219
DP  - 1975 Mar 01
TA  - Journal of Neurology, Neurosurgery & Psychiatry
PG  - 219--224
VI  - 38
IP  - 3
4099  - http://jnnp.bmj.com/content/38/3/219.short
4100  - http://jnnp.bmj.com/content/38/3/219.full
SO  - J Neurol Neurosurg Psychiatry1975 Mar 01; 38
AB  - The absorption of phenytoin was studied in man. It is concluded that phenytoin absorbed from the intestine is recirculated via the bile, so that blood levels do not accurately reflect absorption. Phenytoin is loosely bound to serum proteins and is found in red cells in concentrations similar to those in plasma. It is rapidly lost from the blood stream after intravenous administration, which is an important factor to be considered in the treatment of status epilepticus.