RT Journal Article SR Electronic T1 Studies in man of phenytoin absorption and its implications. JF Journal of Neurology, Neurosurgery & Psychiatry JO J Neurol Neurosurg Psychiatry FD BMJ Publishing Group Ltd SP 219 OP 224 DO 10.1136/jnnp.38.3.219 VO 38 IS 3 A1 F B Gibberd A1 M Webley YR 1975 UL http://jnnp.bmj.com/content/38/3/219.abstract AB The absorption of phenytoin was studied in man. It is concluded that phenytoin absorbed from the intestine is recirculated via the bile, so that blood levels do not accurately reflect absorption. Phenytoin is loosely bound to serum proteins and is found in red cells in concentrations similar to those in plasma. It is rapidly lost from the blood stream after intravenous administration, which is an important factor to be considered in the treatment of status epilepticus.