TY - JOUR T1 - Myxoedematous polyneuropathy: a light and electron microscopic study of the peripheral nerve and muscle. JF - Journal of Neurology, Neurosurgery & Psychiatry JO - J Neurol Neurosurg Psychiatry SP - 241 LP - 247 DO - 10.1136/jnnp.38.3.241 VL - 38 IS - 3 AU - T Shirabe AU - S Tawara AU - A Terao AU - S Araki Y1 - 1975/03/01 UR - http://jnnp.bmj.com/content/38/3/241.abstract N2 - Histopathological findings of biopsied peripheral nerve and muscle were studied in a case with myxoedematous polyneuropathy. The most striking findings in the sural nerve were segmental demyelination and onion bulb formation with scanty mucinous deposits in addition to marked loss of large myelinated nerve fibres. The peroneus brevis muscle revealed the association of neuropathic and myopathic changes. It is suggested that myxoedematous polyneuropathy might be intrinsic neuropathy due to metabolic disorder of Schwann cells related to hypothyroidism, resulting in segmental demyelination, not merely compressive neuropathy due to mucinous deposits in the peripheral nerves. ER -