TY - JOUR T1 - Acetylcholine and choline in cerebrospinal fluid of patients with Parkinson's disease and Huntington's chorea. JF - Journal of Neurology, Neurosurgery & Psychiatry JO - J Neurol Neurosurg Psychiatry SP - 367 LP - 374 DO - 10.1136/jnnp.39.4.367 VL - 39 IS - 4 AU - M J Welch AU - C H Markham AU - D J Jenden Y1 - 1976/04/01 UR - http://jnnp.bmj.com/content/39/4/367.abstract N2 - Lumbar cerebrospinal fluid (CSF) acetylcholine (ACh) and choline (Ch) levels were measured in patients with Huntington's chorea (N=11), Parkinson's disease (N=8), and subjects at risk for Huntington's chorea (N=4), and all three groups were found not to differ significantly from normal controls (N=10). The values found for lumbar CSF ACh and Ch levels in the normal subjects were comparable with previously reported values. The use of physostigmine, a cholinesterase inhibitor, in collecting the CSF samples did not appear to make a difference with regard to ACh and Ch concentrations. Evidence suggesting a ventricular-lumbar gradient, with lumbar CSF Ch concentration being less than ventricular CSF Ch concentration, was found. Finally, ACh levels in CSF did not correlate with corresponding Ch levels. ER -