RT Journal Article
SR Electronic
T1 Acetylcholine and choline in cerebrospinal fluid of patients with Parkinson's disease and Huntington's chorea.
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 367
OP 374
DO 10.1136/jnnp.39.4.367
VO 39
IS 4
A1 M J Welch
A1 C H Markham
A1 D J Jenden
YR 1976
UL http://jnnp.bmj.com/content/39/4/367.abstract
AB Lumbar cerebrospinal fluid (CSF) acetylcholine (ACh) and choline (Ch) levels were measured in patients with Huntington's chorea (N=11), Parkinson's disease (N=8), and subjects at risk for Huntington's chorea (N=4), and all three groups were found not to differ significantly from normal controls (N=10). The values found for lumbar CSF ACh and Ch levels in the normal subjects were comparable with previously reported values. The use of physostigmine, a cholinesterase inhibitor, in collecting the CSF samples did not appear to make a difference with regard to ACh and Ch concentrations. Evidence suggesting a ventricular-lumbar gradient, with lumbar CSF Ch concentration being less than ventricular CSF Ch concentration, was found. Finally, ACh levels in CSF did not correlate with corresponding Ch levels.