RT Journal Article
SR Electronic
T1 Congenital myasthenia gravis: clinical and HLA studies in two brothers.
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 1145
OP 1150
DO 10.1136/jnnp.39.12.1145
VO 39
IS 12
A1 Whiteley, A M
A1 Schwartz, M S
A1 Sachs, J A
A1 Swash, M
YR 1976
UL http://jnnp.bmj.com/content/39/12/1145.abstract
AB Two brothers with congenital myasthenia gravis are described. In both, ptosis and ophthalmoplegia responded poorly to oral anticholinesterase therapy and to thymectomy. The brothers had two different HLA haplotypes and neither had the HLA-A1-B8-DW3 haplotypes which are commonly associated with myathenia gravis in adult-onset cases.