TY - JOUR T1 - Trial of long-term anticoagulant therapy in the treatment of small stroke associated with a normal carotid arteriogram. JF - Journal of Neurology, Neurosurgery & Psychiatry JO - J Neurol Neurosurg Psychiatry SP - 642 LP - 647 DO - 10.1136/jnnp.38.7.642 VL - 38 IS - 7 AU - P Bradshaw AU - S Brennan Y1 - 1975/07/01 UR - http://jnnp.bmj.com/content/38/7/642.abstract N2 - The clinical features of 49 patients who had sustained small strokes in the internal carotid artery territory, who were normotensive, free from cardiac or other relevant disease, and who each had a normal appropriate single vessel angiogram are presented. These were randomized into two groups: group A, 25 patients, who received only supportive treatment; group B, 24 patients who were treated with anticoagulants for an average period of 18 months. There was a reduced incidence of neurological episodes during the administration of anticoagulant therapy but, after treatment was discontinued, there was no significant difference between the two groups. In view of the relatively benign prognosis for this syndrome, unless special facilities exist for the personal control of anticoagulant treatment, the dangers may outweigh the benefits. ER -