%0 Journal Article %A M Takamori %T Nerve, muscle, and serotonin. %D 1977 %R 10.1136/jnnp.40.1.89 %J Journal of Neurology, Neurosurgery & Psychiatry %P 89-96 %V 40 %N 1 %X Effects of serotonin one neuromuscular transmission and muscle contraction were studied in the tibialis anterior of rabbits. Serotonin antagonised the Mg++-induced block of transmission, and also provided dual effects on the curare-induced block, anti-curare phase followed by curare-potentiating phase. Independent of transmission processes, serotonin caused a reduction in twitch tension, mainly associated with decreased acceleration of twitch development. These serotonin actions were independent of vascular changes; pharmacological mechanisms are discussed in comparison with those of adrenaline and isoprenaline. A possible role of serotonin in causing a myopathy is proposed. %U https://jnnp.bmj.com/content/jnnp/40/1/89.full.pdf