RT Journal Article
SR Electronic
T1 Nerve, muscle, and serotonin.
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 89
OP 96
DO 10.1136/jnnp.40.1.89
VO 40
IS 1
A1 M Takamori
YR 1977
UL http://jnnp.bmj.com/content/40/1/89.abstract
AB Effects of serotonin one neuromuscular transmission and muscle contraction were studied in the tibialis anterior of rabbits. Serotonin antagonised the Mg++-induced block of transmission, and also provided dual effects on the curare-induced block, anti-curare phase followed by curare-potentiating phase. Independent of transmission processes, serotonin caused a reduction in twitch tension, mainly associated with decreased acceleration of twitch development. These serotonin actions were independent of vascular changes; pharmacological mechanisms are discussed in comparison with those of adrenaline and isoprenaline. A possible role of serotonin in causing a myopathy is proposed.