PT  - JOURNAL ARTICLE
AU  - Schiller, H H
AU  - Stålberg, E
AU  - Schwartz, M S
TI  - Regional curare for the reduction of the safety factor in human motor end-plates studied with single fibre electromyography.
AID  - 10.1136/jnnp.38.8.805
DP  - 1975 Aug 01
TA  - Journal of Neurology, Neurosurgery & Psychiatry
PG  - 805--809
VI  - 38
IP  - 8
4099  - http://jnnp.bmj.com/content/38/8/805.short
4100  - http://jnnp.bmj.com/content/38/8/805.full
SO  - J Neurol Neurosurg Psychiatry1975 Aug 01; 38
AB  - A method employing six minutes of regional curarization with 0.5 mg D-tubocurarine and single fibre electromyographic measurements (SFEMG) was used in order to study the effect of an additional small dose of D-tubocurarine. The effect of the additional dose was most pronounced in terms of increased jitter, on motor end-plates with the initially highest jitter. The combination of regional curarization and SFEMG jitter recordings offers a sensitive technique for detecting mild effects of various drugs on neuromuscular transmission not detectable with decrement investigations.