RT Journal Article
SR Electronic
T1 Muscle nuclear size in neuromuscular disease.
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 159
OP 162
DO 10.1136/jnnp.39.2.159
VO 39
IS 2
A1 D Vassilopoulos
A1 E M Lumb
A1 A E Emery
YR 1976
UL http://jnnp.bmj.com/content/39/2/159.abstract
AB Nuclear size has been estimated in muscle biopsy specimens from seven healthy individuals, eight patients with infantile spinal muscular atrophy (types I and II), and eight patients with Duchenne muscular dystrophy. The results indicate a great increase in nuclear size in Duchenne muscular dystrophy but not in spinal muscular atrophy when compared with controls. The reasons for this finding are discussed in relation to the pathogenesis of these two groups of diseases.