PT  - JOURNAL ARTICLE
AU  - M G Bramble
AU  - J Cunliffe
AU  - A W Dellipiani
TI  - Evidence for a change in neurotransmitter affecting oesophageal motility in Parkinson's disease.
AID  - 10.1136/jnnp.41.8.709
DP  - 1978 Aug 01
TA  - Journal of Neurology, Neurosurgery & Psychiatry
PG  - 709--712
VI  - 41
IP  - 8
4099  - http://jnnp.bmj.com/content/41/8/709.short
4100  - http://jnnp.bmj.com/content/41/8/709.full
SO  - J Neurol Neurosurg Psychiatry1978 Aug 01; 41
AB  - In a study of oesophageal motility in 20 patients with Parkinson's disease, intravenous atropine produced marked disruption of co-ordination in response to swallows, when compared with control subjects. This suggests that cholinergic rather than dopaminergic mechanisms are more important in the control of swallowing in patients with Parkinsonism. No conclusive evidence of peripheral dopamine depletion or autonomic neuropathy was found, although minor changes suggestive of the former were found in severely affected patients.