RT Journal Article
SR Electronic
T1 Evidence for a change in neurotransmitter affecting oesophageal motility in Parkinson's disease.
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 709
OP 712
DO 10.1136/jnnp.41.8.709
VO 41
IS 8
A1 Bramble, M G
A1 Cunliffe, J
A1 Dellipiani, A W
YR 1978
UL http://jnnp.bmj.com/content/41/8/709.abstract
AB In a study of oesophageal motility in 20 patients with Parkinson's disease, intravenous atropine produced marked disruption of co-ordination in response to swallows, when compared with control subjects. This suggests that cholinergic rather than dopaminergic mechanisms are more important in the control of swallowing in patients with Parkinsonism. No conclusive evidence of peripheral dopamine depletion or autonomic neuropathy was found, although minor changes suggestive of the former were found in severely affected patients.