PT - JOURNAL ARTICLE AU - Bernat, J L AU - Ochoa, J L TI - Muscle hypertrophy after partial denervation: a human case. AID - 10.1136/jnnp.41.8.719 DP - 1978 Aug 01 TA - Journal of Neurology, Neurosurgery & Psychiatry PG - 719--725 VI - 41 IP - 8 4099 - http://jnnp.bmj.com/content/41/8/719.short 4100 - http://jnnp.bmj.com/content/41/8/719.full SO - J Neurol Neurosurg Psychiatry1978 Aug 01; 41 AB - While undergoing long-term physiotherapy, a 41 year old woman with a chronic S1 radiculopathy developed progressive, painless enlargement of the weak calf. Gastrocnemius muscle biopsy disclosed changes of partial denervation and reinnervation, with small groups of type I and type II atrophic muscle fibres and abundant hypertrophic fibres of both types but mostly type II. It is postulated that, in addition to comprensatory work-induced type II muscle fibre hypertrophy, there was an element of (type I) stretched-induced hypertrophy of denervated fibres, a condition well recognised experimentally but not documented in man.