PT  - JOURNAL ARTICLE
AU  - J L Bernat
AU  - J L Ochoa
TI  - Muscle hypertrophy after partial denervation: a human case.
AID  - 10.1136/jnnp.41.8.719
DP  - 1978 Aug 01
TA  - Journal of Neurology, Neurosurgery & Psychiatry
PG  - 719--725
VI  - 41
IP  - 8
4099  - http://jnnp.bmj.com/content/41/8/719.short
4100  - http://jnnp.bmj.com/content/41/8/719.full
SO  - J Neurol Neurosurg Psychiatry1978 Aug 01; 41
AB  - While undergoing long-term physiotherapy, a 41 year old woman with a chronic S1 radiculopathy developed progressive, painless enlargement of the weak calf. Gastrocnemius muscle biopsy disclosed changes of partial denervation and reinnervation, with small groups of type I and type II atrophic muscle fibres and abundant hypertrophic fibres of both types but mostly type II. It is postulated that, in addition to comprensatory work-induced type II muscle fibre hypertrophy, there was an element of (type I) stretched-induced hypertrophy of denervated fibres, a condition well recognised experimentally but not documented in man.