RT Journal Article
SR Electronic
T1 Muscle hypertrophy after partial denervation: a human case.
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 719
OP 725
DO 10.1136/jnnp.41.8.719
VO 41
IS 8
A1 J L Bernat
A1 J L Ochoa
YR 1978
UL http://jnnp.bmj.com/content/41/8/719.abstract
AB While undergoing long-term physiotherapy, a 41 year old woman with a chronic S1 radiculopathy developed progressive, painless enlargement of the weak calf. Gastrocnemius muscle biopsy disclosed changes of partial denervation and reinnervation, with small groups of type I and type II atrophic muscle fibres and abundant hypertrophic fibres of both types but mostly type II. It is postulated that, in addition to comprensatory work-induced type II muscle fibre hypertrophy, there was an element of (type I) stretched-induced hypertrophy of denervated fibres, a condition well recognised experimentally but not documented in man.