TY - JOUR T1 - Tiapride in levodopa-induced involuntary movements. JF - Journal of Neurology, Neurosurgery & Psychiatry JO - J Neurol Neurosurg Psychiatry SP - 380 LP - 383 DO - 10.1136/jnnp.42.4.380 VL - 42 IS - 4 AU - A J Lees AU - C M Lander AU - G M Stern Y1 - 1979/04/01 UR - http://jnnp.bmj.com/content/42/4/380.abstract N2 - Tiapride, a substituted benzamide derivative closely related to metoclopramide, reduced levodopa-induced peak dose involuntary movements in 16 patients with idiopathic Parkinson's disease. However, an unacceptable increase in disability from Parkinsonism with aggravation of end-of-dose akinesia led to its cessation in 14 patients. Tiapride had no effect on levodopa-induced early morning of "off-period" segmental dystonia. These results fail to support the notion that levodopa-induced dyskinesias are caused by overstimulation of a separate group of dopamine receptors. ER -