PT  - JOURNAL ARTICLE
AU  - Hassan, N
AU  - McLellan, D L
TI  - Double-blind comparison of single doses of DS103-282, baclofen and placebo for suppression of spasticity.
AID  - 10.1136/jnnp.43.12.1132
DP  - 1980 Dec 01
TA  - Journal of Neurology, Neurosurgery & Psychiatry
PG  - 1132--1136
VI  - 43
IP  - 12
4099  - http://jnnp.bmj.com/content/43/12/1132.short
4100  - http://jnnp.bmj.com/content/43/12/1132.full
SO  - J Neurol Neurosurg Psychiatry1980 Dec 01; 43
AB  - Twelve spastic patients received single oral doses of a new anti-spastic drug DS103-282 (Sandoz) 6 mg, baclofen 20 mg, and placebo on three separate days. Passive stretch responses were measured before administration and for four hours afterwards. DS103-282 was more effective than baclofen, and both drugs were more effective than placebo. Analysis of the recordings confirmed that DS103-282 had a specific effect upon stretch reflexes independent of its effect on resting muscle tone. Its action appeared at 30 to 45 minutes after ingestion, with maximum activity at 60-90 minutes. Unwanted effects of DS103-282 were drowsiness and (in one case) potentiation of antihypertensive therapy.